TY - JOUR
T1 - Antenatal glucocorticoid treatment does not reduce chronic lung disease among surviving preterm infants
AU - Van Marter, Linda J.
AU - Allred, Elizabeth N.
AU - Leviton, Alan
AU - Pagano, Marcello
AU - Parad, Richard
AU - Moore, Marianne
N1 - Funding Information:
Supported by funds provided by the National Institutes of Neurological Disorders and Stroke (NS 27306) and the National Heart, Lung, and Blood Institute (HL 56398).
PY - 2001
Y1 - 2001
N2 - Background: Antenatal glucocorticoid treatment (AGT) is associated with a number of postnatal benefits to the preterm infant, including reduced risk of respiratory distress syndrome, patent ductus arteriosus, intraventricular hemorrhage, and necrotizing enterocolitis. Objective: To evaluate the hypothesis that maternal AGT not only reduces the risk of surfactant deficiency but also reduces the occurrence of chronic lung disease (CLD) among surviving preterm infants. Study design: Case-referent study of 1454 very low birth weight infants born between January 1991 and December 1995 at 4 university medical centers. Results: Rates of AGT varied among the 4 centers (11%-69%), as did rates of CLD (4%-21%), defined as a requirement for supplemental oxygen at 36 weeks' postmenstrual age. CLD rates at each center, however, did not vary with the rate of AGT exposure. In multivariate logistic regression analyses, AGT did not contribute significantly to CLD risk. Conclusion: AGT may play a less prominent role in modifying CLD risk than other factors such as biologic immaturity, infection, or neonatal intensive care unit practices, such as mechanical ventilation, continuous positive airway pressure, and surfactant replacement therapy.
AB - Background: Antenatal glucocorticoid treatment (AGT) is associated with a number of postnatal benefits to the preterm infant, including reduced risk of respiratory distress syndrome, patent ductus arteriosus, intraventricular hemorrhage, and necrotizing enterocolitis. Objective: To evaluate the hypothesis that maternal AGT not only reduces the risk of surfactant deficiency but also reduces the occurrence of chronic lung disease (CLD) among surviving preterm infants. Study design: Case-referent study of 1454 very low birth weight infants born between January 1991 and December 1995 at 4 university medical centers. Results: Rates of AGT varied among the 4 centers (11%-69%), as did rates of CLD (4%-21%), defined as a requirement for supplemental oxygen at 36 weeks' postmenstrual age. CLD rates at each center, however, did not vary with the rate of AGT exposure. In multivariate logistic regression analyses, AGT did not contribute significantly to CLD risk. Conclusion: AGT may play a less prominent role in modifying CLD risk than other factors such as biologic immaturity, infection, or neonatal intensive care unit practices, such as mechanical ventilation, continuous positive airway pressure, and surfactant replacement therapy.
UR - http://www.scopus.com/inward/record.url?scp=0035137715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035137715&partnerID=8YFLogxK
U2 - 10.1067/mpd.2001.110980
DO - 10.1067/mpd.2001.110980
M3 - Article
C2 - 11233077
AN - SCOPUS:0035137715
SN - 0022-3476
VL - 138
SP - 198
EP - 204
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 2
ER -