Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC)

Objective: Identify antenatal and neonatal factors associated with primary outcome of EUGR. Methods: 1063 preterm infants from a subset of the BBC were included in this prospective cohort study. Regression analysis was carried out to evaluate associations of EUGR with antenatal factors and neonatal factors. Results: 6.1% of the infants had in-utero growth restriction (IUGR) at birth and 21.7% of infants had EUGR. The adjusted odds ratio for EUGR status were significant for birth weight (OR 0.99, p = 0.00, CI 0.99–0.99), for GA at birth (OR 4.58, p = 0.00, CI 3.25–6.44), for PDA (OR 2.9, p = 0.02, CI 1.17–7.1), for NEC (OR 5.14, p = 0.012, CI 1.44–18.3) and for day of life of reaching full feeds (OR 1.04, p = 0.001, CI 1.01–1.06). Conclusion: This study highlights important factors associated with EUGR. Additional studies are needed to gain further insight.