Antecedent bradycardia and in-hospital cardiopulmonary arrest mortality in telemetry-monitored patients outside the ICU

Utpal S. Bhalala, Christopher P. Bonafide, Christian M. Coletti, Penny E. Rathmanner, Vinay M. Nadkarni, Robert A. Berg, Anita K. Witzke, Melody S. Kasprzak, Marc T. Zubrow

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background Patients with in-hospital cardiopulmonary arrest (IHCA) precipitated by respiratory insufficiency often exhibit bradycardia before the arrest. We hypothesized that bradycardia frequently occurs in the 10. min preceding IHCA and is associated with poor outcomes when IHCA occurs outside the intensive care unit (ICU). Objectives: To determine the prevalence and association of antecedent bradycardia with outcome in adult patients with IHCA occurring outside the ICU.Methods We performed a retrospective cohort study among telemetry monitored adults with IHCA outside the ICU in a two-hospital health system between 2008 and 2010 with follow-up until their discharge or death in-hospital.We defined (1) IHCA as >1. min of chest compressions or trans-thoracic defibrillation, (2) Antecedent bradycardia as at least 2. min of continuous heart rate between 1 and 59 beats per minute in the 10. min preceding IHCA, and (3) ventricular tachyarrhythmia arrests as presence of sustained ventricular tachyarrhythmia for >20. s in the 10. min preceding IHCA. Results: Of 98 IHCAs, 39 (39.8%) survived to hospital discharge. Of 98 IHCAs, 53 (54.1%) had antecedent bradycardia. After adjusting for potential confounders, antecedent bradycardia was associated with death prior to hospital discharge (adjusted OR = 3.80, 95%CI: 1.47-9.81, p= 0.006). Among patients with ventricular tachyarrhythmia arrests, antecedent bradycardia was associated with a higher risk of death (OR = 13.1, 95%CI 1.92-89.5, p= 0.009). Conclusions: Antecedent bradycardia occurred frequently and was associated with death prior to hospital discharge in non-ICU hospitalized adults on telemetry monitoring who developed IHCA.

Original languageEnglish (US)
Pages (from-to)1106-1110
Number of pages5
JournalResuscitation
Volume83
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Antecedent bradycardia
  • Code blue patient outcomes
  • ECG telemetry
  • Non-ICU in-hospital cardiopulmonary arrest
  • Pathophysiology
  • Tachydysrhythmia

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

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