Antagonism of lidocaine induced convulsions in the dog by diazepam and pentobarbital

D. C. Jerram, W. F. Hofman, W. C. Hubbard, L. P. Gangarosa

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After control physiological parameter measurements (PPM) were taken, intermittent convulsive seizures (ICS) were induced in atropinized dogs by the intravenous (IV) infusion of 2% lidocaine (L). Five minutes (min) after the onset of ICS, pentobarbital sodium (P), 7.5 mg/kg, or diazepam (D), 0.25 mg/kg, were administered IV. A third group received no treatment. In treated dogs, ICS ceased before the end of the infusion of P (5 mg/kg over 1 to 1.5 min). After 10 min there was generalized muscle relaxation. With D, ICS ceased after 0.05 to 0.1 mg/kg over 15 to 30 sec. Running motions (RM) and increased muscle tone (IMT) continued for periods comparable to those seen in untreated dogs. In untreated dogs, ICS continued for 4.5 to 13.5 min. RM and IMT were manifest for longer periods. The experiments indicate that L induces spontaneous motor activity in the order IMT, tonic extension, RM and ICS. In untreated dogs, the phenomena disappear in reverse order. P abolishes all spontaneous motor activity. D is a potent antagonist of ICS.

Original languageEnglish (US)
Number of pages1
JournalFederation Proceedings
Issue number3 (I)
StatePublished - Jan 1 1973

ASJC Scopus subject areas

  • General Medicine


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