Animal models of gene-environment interactions in schizophrenia

Yavuz Ayhan, Akira Sawa, Christopher A. Ross, Mikhail V. Pletnikov

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


The pathogenesis of schizophrenia and related mental illnesses likely involves multiple interactions between susceptibility genes of small effects and environmental factors. Gene-environment interactions occur across different stages of neurodevelopment to produce heterogeneous clinical and pathological manifestations of the disease. The main obstacle for mechanistic studies of gene-environment interplay has been the paucity of appropriate experimental systems for elucidating the molecular pathways that mediate gene-environment interactions relevant to schizophrenia. Recent advances in psychiatric genetics and a plethora of experimental data from animal studies allow us to suggest a new approach to gene-environment interactions in schizophrenia. We propose that animal models based on identified genetic mutations and measurable environment factors will help advance studies of the molecular mechanisms of gene-environment interplay.

Original languageEnglish (US)
Pages (from-to)274-281
Number of pages8
JournalBehavioural Brain Research
Issue number2
StatePublished - Dec 7 2009


  • DISC1
  • Depression
  • Gene-environment interactions
  • Mouse models
  • Schizophrenia

ASJC Scopus subject areas

  • Behavioral Neuroscience


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