Osteonecrosis is a disease that is characterized by lesions of dead bone, most frequently detected in the subchondral bone of the convex side of the major diarthrodial joints (hips, knees, shoulders, and talus). High-dose corticosteroid therapy is one major risk factor for osteonecrosis. The pathological appearance of osteonecrosis of the femoral head, however, is fairly consistent regardless of the etiology. Depending on the stage of the disease, this includes evidence of bone marrow edema, lipocyte and bone cell necrosis, fibrosis, creeping substitution (new bone lying on dead bone), and the presence of osteoporosis . Hemorrhage within the bone marrow compartment has also been observed in patient specimens from corticosteroid-associated osteonecrosis . Previous investigators have suggested that corticosteroid-associated osteonecrosis has more rapid progression than other etiologies [1, 3]. The mechanisms involved in the development of osteonecrosis [ON] are difficult to explore from clinical samples as they provide a single snapshot at one time point subsequent to the onset of the disease, usually months after the onset of the disease when the symptoms first appear. While some investigators have used corticosteroid-associated animal models to evaluate different potential treatments [4–6], it is not clear whether the results can be extrapolated to the human condition. A better understanding of the pathophysiological mechanisms is needed.
ASJC Scopus subject areas
- General Medicine