Angiotensinogen gene haplotype and hypertension: Interaction with ACE gene I allele

Chia Ti Tsai, Daniele Fallin, Fu Tien Chiang, Juey Jen Hwang, Ling Ping Lai, Kuan Lih Hsu, Chuen Den Tseng, Chiau Suong Liau, Yung Zu Tseng

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


There are many reports demonstrating the association of renin-angiotensin system gene polymorphisms with hypertension in different populations. In the present study, we used haplotype analyses of the angiotensinogen gene with a new permutation-based hypothesis testing method to determine the association between multilocus angiotensinogen gene polymorphisms and hypertension in a relatively homogeneous Taiwanese population. We also genotyped angiotensin-converting enzyme gene insertion/deletion polymorphism and angiotensin II type 1-receptor gene A1166C polymorphism to detect epistatic gene-gene interactions. There were 408 patients with hypertension (hypertensives) and 286 controls. The angiotensinogen gene haplotype frequencies were significantly different between hypertensives and controls, and this finding was only present in subjects with angiotensin-converting enzyme gene II genotypes when the analysis was stratified by genotype of this polymorphism. In addition, the angiotensinogen gene haplotype structure of hypertensives was more heterogeneous than that of controls. Our results showed that angiotensinogen gene haplotypes were associated with hypertension and might act synergistically with I allele of the angiotensin-converting enzyme gene.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
Issue number1
StatePublished - Jan 1 2003
Externally publishedYes


  • Angiotensin-converting enzyme
  • Angiotensinogen
  • Genetics
  • Haplotypes
  • Hypertension, genetic
  • Polymorphism
  • Receptors, angiotensin II

ASJC Scopus subject areas

  • Internal Medicine


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