Angiosarcoma of the uterus: A light microscopic immunohistochemical and ultrastructural study

Gary B. Witkin, Frederic B. Askin, J. Dieter Geratz, Robert L. Reddick

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Pretreatment biopsies in 54 patients with Stage II and 37 patients with Stage III squamouA 71-year-old woman who presented with severe vaginal bleeding was found to have a uterine angiosarcoma after total abdominal hysterectomy and bilateral salpingo-oophorectomy. The diagnosis was confirmed by immunohistochemical studies that showed positive staining of tumor cells for factor VIII-related antigen and by ultrastructural studies revealing vasoformative structures surrounded by a thin basal lamina. Primary vascular tumors of the uterus are rare. The existence of malignant vascular neoplasms of the uterus has been questioned, and at most nine previously reported cases have been generally accepted as valid examples of uterine angiosarcoma. Based on those cases, the prognosis of uterine angiosarcoma is poor. Our studies demonstrate that angiosarcoma does occur in the uterus. Our patient is presently alive with recurrent disease.

Original languageEnglish (US)
Pages (from-to)176-184
Number of pages9
JournalInternational Journal of Gynecological Pathology
Issue number2
StatePublished - Jun 1987
Externally publishedYes


  • Angiosarcoma
  • FVIII-related antigen
  • Uterine sarcoma
  • Vascular neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology


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