Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models

Mi Sook Lee, Eun Joung Moon, Sae Won Lee, Myoung Sook Kim, Kyu Won Kim, Yung Jin Kim

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


The excessive growth of a tumor requires high rates of glucose uptake and glycolysis and continuous recruitment of new blood vessels. Here, we provide several lines of evidence showing that pyruvic acid, the end product of glycolysis, exhibits strong angiogenic activity. Pyruvic acid promoted angiogenesis in chorioallantoic membrane assay and in vivo mouse Matrigel plug assay. Pyruvic acid also positively affects angiogenic cascade, DNA synthesis, migration, and tube formation in bovine aortic endothelial cells. Furthermore, mRNA expression of fibroblast growth factor receptor-2 and vascular endothelial growth factor was enhanced by pyruvic acid. These results strongly suggest that pyruvic acid plays an important role in angiogenesis for tumor growth and metastasis.

Original languageEnglish (US)
Pages (from-to)3290-3293
Number of pages4
JournalCancer Research
Issue number8
StatePublished - Apr 15 2001
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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