Abstract
Introduction: Angiogenesis, for its fundamental role in cancer growth and metastasis, has become an appealing target in cancer therapy. A number of angiogenesis-related microRNAs (miRNAs) are under investigation and they can affect the cancerous phenotype of malignant cells. Areas covered: The authors review the recent advances in angiogenesis-related miRNAs in human colon cancer. They also envisage future developments toward potential miRNA-based applications to cancer treatment. Expert opinion: Angiogenesis-related miRNAs may reasonably be considered as a valuable cancer therapeutic tool. More investigations should be performed to promote therapeutic-clinical research of miRNAs in patients with colon cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 77-84 |
| Number of pages | 8 |
| Journal | Expert Opinion on Biological Therapy |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2013 |
Keywords
- Angiogenesis
- Colon cancer
- MiR-107
- MiR-145
- MiR-194
- MiR-27a
- MiR-802
- MicroRNA
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
- Clinical Biochemistry