Angiogenesis and intramembranous osteogenesis

Christopher J. Percival, Joan T. Richtsmeier

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


Background: Angiogenesis is likely critical for the process of intramembranous osteogenesis; however, the developmental relationship between blood vessels and bone mineralization is not well studied within intramembranous bones. Given its importance, changes in angiogenesis regulation are likely to contribute to evolutionarily and medically relevant craniofacial variation. Results: We summarize what is known about the association between angiogenesis and intramembranous osteogenesis, supplementing with information from the better-studied processes of endochondral ossification and distraction osteogenesis. Based on this review, we introduce a model of angiogenesis during early intramembranous osteogenesis as well as a series of null hypotheses to be tested. Conclusions: This model can serve as a basis of future research on the spatio-temporal association and regulatory interactions of mesenchymal, vascular, and bone cells, which will be required to illuminate the potential effects of angiogenesis dysregulation on craniofacial skeletal phenotypes. Developmental Dynamics 242:909-922, 2013.

Original languageEnglish (US)
Pages (from-to)909-922
Number of pages14
JournalDevelopmental Dynamics
Issue number8
StatePublished - Aug 2013
Externally publishedYes


  • Craniofacial development
  • Intramembranous ossification
  • Vascular invasion

ASJC Scopus subject areas

  • Developmental Biology


Dive into the research topics of 'Angiogenesis and intramembranous osteogenesis'. Together they form a unique fingerprint.

Cite this