TY - JOUR
T1 - Anergy for delayed-type hypersensitivity in preleukemic akr mic1, 2
AU - Burdick, James F.
AU - Williams, G. Melville
N1 - Funding Information:
I Received July 3, 1984; accepted November 27, 1984. 2Supported by Public Health Service grant AI-1508l from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by Johns Hopkins University Institutional Research Grant RR·05378·l7. 3 Department of Surgery, Division of Transplantation and Vascular Surgery, The Johns Hopkins Hospital, 600 North Wolfe St., Baltimore, MD 21205. 4 4-(2-Hydroxyethyl)-I-piperazine ethanesulfonic acid.
PY - 1985/5/1
Y1 - 1985/5/1
N2 - A singular anergy for delayed-type hypersensitivity (DTH) in preleukemic AKR mice was discovered. This total anergy for DTH against allogeneic cells, which developed in the AKR mice by 4 to 5 months of age, was not due to an artifact of route of sensitization or of other assay parameters and was not found in other strains sharing H-2 or other genetic background. The mice had an intact capacity to be stimulated in mixed lymphocyte culture to produce cytotoxic effector cells. Although the relationship to lymphoma was not directly addressed in these experiments, the genetic and temporal characteristics of this anergy suggest a biologically important relationship to the preleukemic state.
AB - A singular anergy for delayed-type hypersensitivity (DTH) in preleukemic AKR mice was discovered. This total anergy for DTH against allogeneic cells, which developed in the AKR mice by 4 to 5 months of age, was not due to an artifact of route of sensitization or of other assay parameters and was not found in other strains sharing H-2 or other genetic background. The mice had an intact capacity to be stimulated in mixed lymphocyte culture to produce cytotoxic effector cells. Although the relationship to lymphoma was not directly addressed in these experiments, the genetic and temporal characteristics of this anergy suggest a biologically important relationship to the preleukemic state.
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U2 - 10.1093/jnci/74.5.1089
DO - 10.1093/jnci/74.5.1089
M3 - Article
C2 - 3158770
AN - SCOPUS:0021875772
SN - 0027-8874
VL - 74
SP - 1089
EP - 1093
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 5
ER -