@article{d7ba09490d1f4c3492b1f39d8d624f8d,
title = "Androgen, estrogen and progesterone receptors of the R3327H Copenhagen rat prostatic tumor",
abstract = "Sucrose density gradient analysis of the R3327H tumor cytosol demonstrated the presence of both androgen and estrogen binding proteins. Competitive binding analysis with 17β-estradiol, 5α-dihydrotestosterone, R1881, cyproterone acetate, and cortisol was consistent with the presence of 2 different binding sites for androgens and estrogens. Scatchard binding analysis was performed in the dorsal-lateral prostate as well as the R3327H tumor from normal Copenhagen rats. High affinity receptors for androgen and estrogen but not progesterone were found. However, in R3327H tumors relapsing following castration, the presence of high affinity receptors for progesterone were readily detectable.",
author = "Heston, {W. D.W.} and M. Menon and C. Tananis and Walsh, {P. C.}",
note = "Funding Information: Initial studies by Voigt and DunrLing \[I0\] demonstrated the androgen dependence of the Copenhagen prostatic tumor by showing that the tumor grows best in males, tess well in f~males and !east well in cast::ated male Copenhagen rats. Smolev et al. \[9\]f urther showed the androgen dependence of the growth of the tumor in that the non-steroidal antiandrogen flu:Lam:ides uppressed the growth of the tumor as much as castration. Furthermore, the main effect of andzogen deprivation was to reduce the apparent number of cells which grew from the original implant by 75--95%. This suggested that there were 2 populations of R3327H tumor cells; 1 androgen dependent lind 1 androgen independent. However, testosterone, even in hyperphysiological concentrations, *Supported in part by Public Health Service grant CA-16924 from the National Cancer Institute, National Institutes of Health, Education and Welfare. Reprint requests sho~ld be addressed to: W.D.W. Heston, WashingtonU niversity School of Medicine, Division of Urology, St. Louis, Mi,~souri 63110, U.S.A.",
year = "1979",
month = jan,
doi = "10.1016/S0304-3835(79)80019-1",
language = "English (US)",
volume = "6",
pages = "45--50",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",
}