@article{eb37e8dc4843466f95c32d974a969004,
title = "Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen",
abstract = "To understand the T cell response to prostate cancer, we created transgenic mice that express a model antigen in a prostate-restricted pattern and crossed these animals to TRAMP mice that develop spontaneous prostate cancer. Adoptive transfer of prostate-specific CD4 T cells shows that, in the absence of prostate cancer, the prostate gland is mostly ignored. Tumorigenesis allows T cell recognition of the prostate gland - but this recognition is tolerogenic, resulting in abortive proliferation and ultimately in hyporesponsiveness at the systemic level. Androgen ablation (the most common treatment for metastatic prostate cancer) was able to mitigate this tolerance - allowing prostate-specific T cells to expand and develop effector function after vaccination. These results suggest that immunotherapy for prostate cancer may be most efficacious when administered after androgen ablation.",
author = "Drake, {Charles G.} and Doody, {Amy D.H.} and Mihalyo, {Marianne A.} and Huang, {Ching Tai} and Erin Kelleher and Sowmya Ravi and Hipkiss, {Edward L.} and Flies, {Dallas B.} and Kennedy, {Eugene P.} and Meixiao Long and McGary, {Patrick W.} and Lee Coryell and Nelson, {William G.} and Pardoll, {Drew M.} and Adler, {Adam J.}",
note = "Funding Information: We thank Dr. Linda Sherman for providing the clone 4 mice, as well as Drs. Norman Greenberg and Franco DeMayo for assistance in generating the Pro-HA mice. This work was supported by National Institutes of Health Grants CA109339 and AI49813 as well as Research Scholar Grant RSG-02-235-01-LIB from the American Cancer Society (to A.J.A.), a National Cancer Institute Prostate SPORE grant (CA-58236, to D.M.P and C.G.D.), and NCI grant CA096948 (to C.G.D.). C.G.D. is a Damon Runyon-Lilly Clinical Investigator and was the recipient of a Faculty Recruitment grant from the Maryland Cigarette Restitution Fund.",
year = "2005",
month = mar,
doi = "10.1016/j.ccr.2005.01.027",
language = "English (US)",
volume = "7",
pages = "239--249",
journal = "Cancer cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",
}