Ancillary Activity: Beyond Core Metabolism in Immune Cells

Daniel J. Puleston; Matteo Villa; Erika L. Pearce

doi:10.1016/j.cmet.2017.06.019

Ancillary Activity: Beyond Core Metabolism in Immune Cells

Daniel J. Puleston, Matteo Villa, Erika L. Pearce

Research output: Contribution to journal › Review article › peer-review

Abstract

Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is less well understood. Here we survey the literature and highlight recent advances in our understanding of several ancillary metabolic pathways and how they support processes beyond ATP production and ultimately contribute to protective immunity. In this review article, Puleston et al. highlight the role of auxiliary metabolic pathways in immune cell function. The biosynthesis of polyamines, cholesterol, hexosamines, and nucleotides not only supports core metabolism, but also critically influences the immune response.

Original language	English (US)
Pages (from-to)	131-141
Number of pages	11
Journal	Cell Metabolism
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2017.06.019
State	Published - Jul 5 2017
Externally published	Yes

Keywords

O-GlcNAcylation
cholesterol
hexosamine synthesis pathway
immune cell metabolism
immunity
metabolism
nucleotides
one-carbon metabolism
pentose phosphate pathway
polyamines

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2017.06.019

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abstract = "Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is less well understood. Here we survey the literature and highlight recent advances in our understanding of several ancillary metabolic pathways and how they support processes beyond ATP production and ultimately contribute to protective immunity. In this review article, Puleston et al. highlight the role of auxiliary metabolic pathways in immune cell function. The biosynthesis of polyamines, cholesterol, hexosamines, and nucleotides not only supports core metabolism, but also critically influences the immune response.",

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AU - Puleston, Daniel J.

AU - Villa, Matteo

AU - Pearce, Erika L.

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AB - Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is less well understood. Here we survey the literature and highlight recent advances in our understanding of several ancillary metabolic pathways and how they support processes beyond ATP production and ultimately contribute to protective immunity. In this review article, Puleston et al. highlight the role of auxiliary metabolic pathways in immune cell function. The biosynthesis of polyamines, cholesterol, hexosamines, and nucleotides not only supports core metabolism, but also critically influences the immune response.

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KW - cholesterol

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KW - immune cell metabolism

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KW - metabolism

KW - nucleotides

KW - one-carbon metabolism

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Ancillary Activity: Beyond Core Metabolism in Immune Cells

Abstract

Keywords

ASJC Scopus subject areas

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