Ancestry of African Americans with sickle cell disease

Nadia Solovieff; Stephen W. Hartley; Clinton T. Baldwin; Elizabeth S. Klings; Mark T. Gladwin; James G. Taylor; Gregory J. Kato; Lindsay A. Farrer; Martin H. Steinberg; Paola Sebastiani

doi:10.1016/j.bcmd.2011.04.002

Ancestry of African Americans with sickle cell disease

Nadia Solovieff, Stephen W. Hartley, Clinton T. Baldwin, Elizabeth S. Klings, Mark T. Gladwin, James G. Taylor, Gregory J. Kato, Lindsay A. Farrer, Martin H. Steinberg, Paola Sebastiani

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu.

Original language	English (US)
Pages (from-to)	41-45
Number of pages	5
Journal	Blood Cells, Molecules, and Diseases
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/j.bcmd.2011.04.002
State	Published - Jun 15 2011
Externally published	Yes

Keywords

Admixture
Genetic ancestry
Genetic association
Sickle cell disease

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Hematology
Cell Biology

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10.1016/j.bcmd.2011.04.002

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title = "Ancestry of African Americans with sickle cell disease",

abstract = "The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu.",

keywords = "Admixture, Genetic ancestry, Genetic association, Sickle cell disease",

author = "Nadia Solovieff and Hartley, {Stephen W.} and Baldwin, {Clinton T.} and Klings, {Elizabeth S.} and Gladwin, {Mark T.} and Taylor, {James G.} and Kato, {Gregory J.} and Farrer, {Lindsay A.} and Steinberg, {Martin H.} and Paola Sebastiani",

note = "Funding Information: Supported by NIH grants R01 HL 87681 and R01 HL 068970 (MHS), R01 AG09029 and R01 AG025259 (LAF).",

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doi = "10.1016/j.bcmd.2011.04.002",

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T1 - Ancestry of African Americans with sickle cell disease

AU - Solovieff, Nadia

AU - Hartley, Stephen W.

AU - Baldwin, Clinton T.

AU - Klings, Elizabeth S.

AU - Gladwin, Mark T.

AU - Taylor, James G.

AU - Kato, Gregory J.

AU - Farrer, Lindsay A.

AU - Steinberg, Martin H.

AU - Sebastiani, Paola

N1 - Funding Information: Supported by NIH grants R01 HL 87681 and R01 HL 068970 (MHS), R01 AG09029 and R01 AG025259 (LAF).

PY - 2011/6/15

Y1 - 2011/6/15

N2 - The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu.

AB - The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu.

KW - Admixture

KW - Genetic ancestry

KW - Genetic association

KW - Sickle cell disease

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Ancestry of African Americans with sickle cell disease

Abstract

Keywords

ASJC Scopus subject areas

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