Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

Keyphrases

• Null Mice 100%
• Motor Function 100%
• Sociability 100%
• Metabolomics 100%
• Methyl-CpG-binding Protein 2 (MeCP2) 100%
• Anaplerotic 100%
• Substrate Use 100%
• Triheptanoin 100%
• Rett Syndrome 80%
• Knock-in Mouse Model 40%
• Skeletal muscle 40%
• Tricarboxylic Acid Cycle (TCA cycle) 40%
• Metabolic Imbalance 40%
• Substrate Utilization 40%
• Seizure 20%
• Liver 20%
• Adiponectin 20%
• Social Interaction 20%
• Disability 20%
• Ataxia 20%
• Glucose Tolerance 20%
• Insulin Sensitivity 20%
• Adiposity 20%
• Glucose-insulin System 20%
• Fatty Acids 20%
• Mitochondrial Dysfunction 20%
• Dietary Supplementation 20%
• Hemizygous 20%
• Autism Spectrum Disorder 20%
• Male Mice 20%
• Brain Development 20%
• Serum Leptin 20%
• Energy Production 20%
• Diet Therapy 20%
• Biochemical Pathways 20%
• X-linked 20%
• Psychomotor 20%
• Leptin 20%
• Adipokines 20%
• Untargeted Metabolomics 20%
• Tolerance Sensitivity 20%
• Energy-dependent 20%
• Energy Deficit 20%
• Metabolic Phenotype 20%
• Serum Insulin 20%
• Mitochondrial Morphology 20%
• MECP2 mutation 20%
• Metabolic Health 20%
• Energy Deficiency 20%
• TCA Cycle Intermediates 20%
• Nutrient Substrate 20%
• Symptom Onset 20%
• Abnormal Level 20%
• Increased Longevity 20%
• Function Interaction 20%
• Anaplerotic Therapy 20%

Biochemistry, Genetics and Molecular Biology

• Lifespan 100%
• Binding Protein 100%
• Knockout Mouse 100%
• Metabolome 100%
• Rett Syndrome 100%
• Motor Performance 100%
• Triheptanoin 100%
• Skeletal Muscle 50%
• Leptin 50%
• Glucose 50%
• Intellectual Disability 25%
• Brain Development 25%
• Energy Yield 25%
• Insulin Sensitivity 25%
• Metabolomics 25%
• Adipokine 25%
• MECP2 25%
• Social Interaction 25%
• Mitochondrial Disorder 25%
• Adiponectin 25%
• Deficiency 25%
• Insulin 25%
• Biochemical Pathway 25%
• Fatty Acid 25%

Neuroscience

• Rett Syndrome 100%
• Methyl CpG Binding Protein 2 100%
• Metabolome 100%
• Triheptanoin 100%
• Skeletal Muscle 50%
• Leptin 50%
• Insulin 50%
• Glucose 50%
• Ataxia 25%
• Brain Development 25%
• Fatty Acids 25%
• Social Interaction 25%
• Adipokine 25%
• Adiponectin 25%
• MECP2 25%
• Intellectual Disability 25%
• Autism Spectrum Disorder 25%
• Critical Period 25%