Abstract
We isolated genomic fragments containing the 5′ region of the human type I insulin-like growth factor receptor gene. A unique transcription start site was identified, defining a 1038 bp 5′-untranslated region. No TATA or CCAAT elements were identified in the proximal 480 nucleotides of 5′-flanking region. The region surrounding the transcription start site was similar to a recently described "initiator" sequence. The 5′-flanking and 5′-untranslated regions were highly GC-rich, with numerous potential Sp1 binding sites. A potential AP-2 binding site was identified in the 5′-flanking region and a potential thyroid response element was identified in the 5′-untranslated region. The 5′ region of the human gene was very similar to that of the rat gene, with conservation of many of the potential regulatory elements.
Original language | English (US) |
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Pages (from-to) | 1113-1120 |
Number of pages | 8 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 177 |
Issue number | 3 |
DOIs | |
State | Published - Jun 28 1991 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology