Analysis of the DRPLA triplet repeat in brain tissue and leukocytes from schizophrenics

L. Jones Brando; R. Yolken; M. M. Herman; J. E. Kleinman; C. A. Ross; E. F. Torrey

doi:10.1097/00041444-199621000-00001

Analysis of the DRPLA triplet repeat in brain tissue and leukocytes from schizophrenics

L. Jones Brando, R. Yolken, M. M. Herman, J. E. Kleinman, C. A. Ross, E. F. Torrey

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An expansion of the CAG triplet in the human gene called atrophin-1 or CTG-B37 causes the neuropsychiatric disease known as dentatorubral-pallidoluysian atrophy (DRPLA). We have examined the genomic DNA from brains and peripheral blood leukocytes (PBLs) of schizophrenic and non-schizophrenic individuals and PBLs from a cohort of monozygotic twins discordant or concordant for schizophrenia, for expansions of the CTG-B37 region. All samples, including non-schizophrenic/normal controls, had 7-22 CAG repeats in this region. Thus we found no evidence for an expansion of the DRPLA triplet repeat associated with schizophrenia when compared to controls. Our data suggest that an expansion in the CTG-B37 gene is not linked to or responsible for the disease schizophrenia.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Psychiatric genetics
Volume	6
Issue number	1
DOIs	https://doi.org/10.1097/00041444-199621000-00001
State	Published - Jan 1 1996

Keywords

DRPLA
Schizophrenia
Triplet repeats

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

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10.1097/00041444-199621000-00001

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title = "Analysis of the DRPLA triplet repeat in brain tissue and leukocytes from schizophrenics",

abstract = "An expansion of the CAG triplet in the human gene called atrophin-1 or CTG-B37 causes the neuropsychiatric disease known as dentatorubral-pallidoluysian atrophy (DRPLA). We have examined the genomic DNA from brains and peripheral blood leukocytes (PBLs) of schizophrenic and non-schizophrenic individuals and PBLs from a cohort of monozygotic twins discordant or concordant for schizophrenia, for expansions of the CTG-B37 region. All samples, including non-schizophrenic/normal controls, had 7-22 CAG repeats in this region. Thus we found no evidence for an expansion of the DRPLA triplet repeat associated with schizophrenia when compared to controls. Our data suggest that an expansion in the CTG-B37 gene is not linked to or responsible for the disease schizophrenia.",

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AU - Jones Brando, L.

AU - Yolken, R.

AU - Herman, M. M.

AU - Kleinman, J. E.

AU - Ross, C. A.

AU - Torrey, E. F.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - An expansion of the CAG triplet in the human gene called atrophin-1 or CTG-B37 causes the neuropsychiatric disease known as dentatorubral-pallidoluysian atrophy (DRPLA). We have examined the genomic DNA from brains and peripheral blood leukocytes (PBLs) of schizophrenic and non-schizophrenic individuals and PBLs from a cohort of monozygotic twins discordant or concordant for schizophrenia, for expansions of the CTG-B37 region. All samples, including non-schizophrenic/normal controls, had 7-22 CAG repeats in this region. Thus we found no evidence for an expansion of the DRPLA triplet repeat associated with schizophrenia when compared to controls. Our data suggest that an expansion in the CTG-B37 gene is not linked to or responsible for the disease schizophrenia.

AB - An expansion of the CAG triplet in the human gene called atrophin-1 or CTG-B37 causes the neuropsychiatric disease known as dentatorubral-pallidoluysian atrophy (DRPLA). We have examined the genomic DNA from brains and peripheral blood leukocytes (PBLs) of schizophrenic and non-schizophrenic individuals and PBLs from a cohort of monozygotic twins discordant or concordant for schizophrenia, for expansions of the CTG-B37 region. All samples, including non-schizophrenic/normal controls, had 7-22 CAG repeats in this region. Thus we found no evidence for an expansion of the DRPLA triplet repeat associated with schizophrenia when compared to controls. Our data suggest that an expansion in the CTG-B37 gene is not linked to or responsible for the disease schizophrenia.

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KW - Schizophrenia

KW - Triplet repeats

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Analysis of the DRPLA triplet repeat in brain tissue and leukocytes from schizophrenics

Abstract

Keywords

ASJC Scopus subject areas

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