A mathematical model of oxygen transport in the precapicallary microcirculation is presented. The theory is then used to simulate oxygen distribution in the arteriolar network of the hamster cheek pouch. Theoretical prediction of transmural and longitudinal oxygen tension (PO2) gradients is in qualitative agreement with available experimental data. The effect of the variation of inlet network PO2, blood flow rate, blood hematocrit, and other parameters on the transport characteristics is studied. The calculations predict that the luminal PO2 in small arterioles is practically independent of the inlet network PO2 level, if the latter is sufficiently high: when this inlet PO2 level is low, then the longitudinal gradients of luminal PL2 vanish. It is further shown that retardation of blood flow may cause a significant increase in precapillary oxygen losses.
|American Journal of Physiology - Heart and Circulatory Physiology
|Published - 1979
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)