Analysis of interpolation effects in the reslicing of functional MR images

John L. Ostuni, Attanagoda K.S. Santha, Venkata S. Mattay, Daniel R. Weinberger, Ronald L. Levin, Joseph A. Frank

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Purpose: Typically, the final step in volume registration is the reslicing of the volume of interest. The purpose of this work is to examine the effects of this reslicing on functional MRI (fMRI) data using different interpolation methods. Method: Functional whole-brain echo planar imaging (EPI) volumes were resliced using six different interpolation methods: trilinear, tricubic splines, and a 3D sinc function using a rectangular and a Hanning window, both with half-window lengths of 3 and 4 voxels. Results: Interpolation by tricubic spline and 3D sinc using a Henning window had comparable errors, although tricubic spline interpolation was computationally the fastest. Interpolation by trilinear and 3D sinc using a rectangular window had relatively large errors, although the speed of trilinear makes it desirable for some applications. Conclusion: Interpolations using all of the tested methods adversely affected the fMRI data, although these effects differed for each method.

Original languageEnglish (US)
Pages (from-to)803-810
Number of pages8
JournalJournal of computer assisted tomography
Issue number5
StatePublished - 1997
Externally publishedYes


  • Echo planar imaging
  • Image registration
  • Magnetic resonance imaging, functional
  • Magnetic resonance imaging, physics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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