TY - JOUR
T1 - Analysis of HPC1, HPCX, and PCaP in Icelandic hereditary prostate cancer
AU - Bergthorsson, Jon
AU - Johannesdottir, Gudrun
AU - Arason, Adalgeir
AU - Benediktsdottir, Kristrun
AU - Agnarsson, Bjarni
AU - Bailey-Wilson, Joan
AU - Gillanders, Elizabeth
AU - Smith, Jeffrey
AU - Trent, Jeff
AU - Barkardottir, Rosa
N1 - Funding Information:
Acknowledgements The authors thank Professor Jonas Hall-grimsson and staff at the Department of Pathology, especially K. Olafsdottir, S. Kristjansdottir, and D. Ludviksdottir for processing the paraffin tissue slices. We also gratefully acknowledge the contributions of A. G. Hafsteinsdottir and O. Vilhjalmsdottir of the Genetic Committee of the University of Iceland, and O. Kristins-son of the Computer Department of the University Hospital for assistance with database searches. This work was supported by a grant from the Science Fund of Iceland.
PY - 2000
Y1 - 2000
N2 - Putative prostate cancer susceptibility loci have recently been identified by genetic linkage analysis on chromosomes 1q24-25 (HPC1), 1q44.2-43 (PCaP), and Xq27-28 (HPCX). In order to estimate the genetic linkage in Icelandic prostate cancer families, we genotyped 241 samples from 87 families with eleven markers in the HPC1 region, six markers at PCaP, and eight at HPCX. Concurrently, we assessed allelic imbalance at the HPC1 and PCaP loci in selected tumors from the patients. For each of the candidate regions, the combined parametric and non-parametric LOD scores were strongly negative. Evidence for linkage allowing for genetic heterogeneity was also insignificant for all the regions. The results were negative irrespective of whether calculations were performed for the whole material or for a selected set of early age at onset families. The prevalence of allelic imbalance was relatively low in both the HPC1 (0%-9%) and PCaP (5%-20%) regions and was not elevated in tumors from positively linked families. Our studies indicate that the putative cancer susceptibility genes at chromosomes 1q24-25, 1q44.2-43, and Xq27-28 are unlikely to contribute significantly to hereditary prostate cancer in Iceland and that selective loss of the HPC1 and PCaP loci is a relatively rare somatic event in prostate cancers.
AB - Putative prostate cancer susceptibility loci have recently been identified by genetic linkage analysis on chromosomes 1q24-25 (HPC1), 1q44.2-43 (PCaP), and Xq27-28 (HPCX). In order to estimate the genetic linkage in Icelandic prostate cancer families, we genotyped 241 samples from 87 families with eleven markers in the HPC1 region, six markers at PCaP, and eight at HPCX. Concurrently, we assessed allelic imbalance at the HPC1 and PCaP loci in selected tumors from the patients. For each of the candidate regions, the combined parametric and non-parametric LOD scores were strongly negative. Evidence for linkage allowing for genetic heterogeneity was also insignificant for all the regions. The results were negative irrespective of whether calculations were performed for the whole material or for a selected set of early age at onset families. The prevalence of allelic imbalance was relatively low in both the HPC1 (0%-9%) and PCaP (5%-20%) regions and was not elevated in tumors from positively linked families. Our studies indicate that the putative cancer susceptibility genes at chromosomes 1q24-25, 1q44.2-43, and Xq27-28 are unlikely to contribute significantly to hereditary prostate cancer in Iceland and that selective loss of the HPC1 and PCaP loci is a relatively rare somatic event in prostate cancers.
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U2 - 10.1007/s004390000384
DO - 10.1007/s004390000384
M3 - Article
C2 - 11129338
AN - SCOPUS:0033758108
SN - 0340-6717
VL - 107
SP - 372
EP - 375
JO - Human genetics
JF - Human genetics
IS - 4
ER -