Analysis of Busulfan in Plasma by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Abed Pablo, Autumn R. Breaud, William Clarke

Research output: Contribution to journalArticlepeer-review


Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is an important analytical method for quantification of busulfan in plasma in order to optimize the dose.

Original languageEnglish (US)
Article numbere93
JournalCurrent Protocols in Toxicology
Issue number1
StatePublished - Jun 1 2020


  • bone marrow transplantation
  • busulfan
  • chromatography
  • tandem mass spectrometry
  • therapeutic drug monitoring

ASJC Scopus subject areas

  • Toxicology


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