ANALGESIC EFFICACY OF PARENTERAL METKEPHAMID ACETATE IN TREATMENT OF POSTOPERATIVE PAIN

J. F. Calimlim; K. Sriwatanakul; William M. Wardell; L. Lasagna; C. Cox

doi:10.1016/S0140-6736(82)92497-7

ANALGESIC EFFICACY OF PARENTERAL METKEPHAMID ACETATE IN TREATMENT OF POSTOPERATIVE PAIN

J. F. Calimlim, K. Sriwatanakul, William M. Wardell, L. Lasagna, C. Cox

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Abstract

The analgesic efficacy and side-effects of a single parenteral dose of metkephamid acetate 70 mg were compared with those of pethidine (meperidine) hydrochloride 100 mg and placebo in a double-blind, randomised, controlled clinical trial. 30 out of 32 postoperative patients completed the study-10 in the metkephamid group, 11 in the pethidine group, and 9 in the placebo group. The time-effect curves of summated pain measures and analyses of derived measures all indicated that the analgesic activity of metkephamid 70 mg was significantly greater than that of placebo and not less than that of pethidine 100 mg. The metkephamid group had a greater incidence of side-effects than the other two treatment groups. Some side-effects, such as sensations of heaviness of the extremities and nasal congestion, were peculiar to metkephamid but not distressing.

Original language	English (US)
Pages (from-to)	1374-1375
Number of pages	2
Journal	The Lancet
Volume	319
Issue number	8286
DOIs	https://doi.org/10.1016/S0140-6736(82)92497-7
State	Published - Jun 19 1982
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "ANALGESIC EFFICACY OF PARENTERAL METKEPHAMID ACETATE IN TREATMENT OF POSTOPERATIVE PAIN",

abstract = "The analgesic efficacy and side-effects of a single parenteral dose of metkephamid acetate 70 mg were compared with those of pethidine (meperidine) hydrochloride 100 mg and placebo in a double-blind, randomised, controlled clinical trial. 30 out of 32 postoperative patients completed the study-10 in the metkephamid group, 11 in the pethidine group, and 9 in the placebo group. The time-effect curves of summated pain measures and analyses of derived measures all indicated that the analgesic activity of metkephamid 70 mg was significantly greater than that of placebo and not less than that of pethidine 100 mg. The metkephamid group had a greater incidence of side-effects than the other two treatment groups. Some side-effects, such as sensations of heaviness of the extremities and nasal congestion, were peculiar to metkephamid but not distressing.",

author = "Calimlim, {J. F.} and K. Sriwatanakul and Wardell, {William M.} and L. Lasagna and C. Cox",

note = "Funding Information: This study was supported by Eli Lilly & Company. We thank Mr William Kelvie for his technical assistance. Correspondence should be addressed to J. Anesthesiology, University of Rochester Medical York 14642, U.S.A.",

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doi = "10.1016/S0140-6736(82)92497-7",

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AU - Calimlim, J. F.

AU - Sriwatanakul, K.

AU - Wardell, William M.

AU - Lasagna, L.

AU - Cox, C.

N1 - Funding Information: This study was supported by Eli Lilly & Company. We thank Mr William Kelvie for his technical assistance. Correspondence should be addressed to J. Anesthesiology, University of Rochester Medical York 14642, U.S.A.

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N2 - The analgesic efficacy and side-effects of a single parenteral dose of metkephamid acetate 70 mg were compared with those of pethidine (meperidine) hydrochloride 100 mg and placebo in a double-blind, randomised, controlled clinical trial. 30 out of 32 postoperative patients completed the study-10 in the metkephamid group, 11 in the pethidine group, and 9 in the placebo group. The time-effect curves of summated pain measures and analyses of derived measures all indicated that the analgesic activity of metkephamid 70 mg was significantly greater than that of placebo and not less than that of pethidine 100 mg. The metkephamid group had a greater incidence of side-effects than the other two treatment groups. Some side-effects, such as sensations of heaviness of the extremities and nasal congestion, were peculiar to metkephamid but not distressing.

AB - The analgesic efficacy and side-effects of a single parenteral dose of metkephamid acetate 70 mg were compared with those of pethidine (meperidine) hydrochloride 100 mg and placebo in a double-blind, randomised, controlled clinical trial. 30 out of 32 postoperative patients completed the study-10 in the metkephamid group, 11 in the pethidine group, and 9 in the placebo group. The time-effect curves of summated pain measures and analyses of derived measures all indicated that the analgesic activity of metkephamid 70 mg was significantly greater than that of placebo and not less than that of pethidine 100 mg. The metkephamid group had a greater incidence of side-effects than the other two treatment groups. Some side-effects, such as sensations of heaviness of the extremities and nasal congestion, were peculiar to metkephamid but not distressing.

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ANALGESIC EFFICACY OF PARENTERAL METKEPHAMID ACETATE IN TREATMENT OF POSTOPERATIVE PAIN

Abstract

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