Anaesthesia of nyala (Tragelaphus angasi) with a combination of thiafentanil (A3080), medetomidine and ketamine

D. V. Cooper, D. Grobler, M. Bush, D. Jessup, W. Lance

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


A combination of thiafentanil (A3080), medetomidine hydrochloride (MED) and ketamine drochloride (KET) was evaluated in 19 boma-habituated (12 female and 7 males) and 9 free-ranging nyala (7 male and 2 females) (Tragelaphus angasi) to develop a safe and reliable anaesthesia protocol. Wide dosages were used safely during this study with ranges for A3080 of 45 ± 8 μg/kg with MED of 69 ± 19 μg/kg and KET of 3.7 ± 1.0 mg/kg (200 mg/ animal). The dosages developed on boma-habituated nyala proved to be equally effective in 9 adult free-ranging nyala (7 males and 2 females). The optimum dosage for nyala was a combination of A3080 (40-50, μg/kg), MED (60-80 μg/kg) plus 200 mg of KET/animal. The anaesthesia was characterised by a short induction, good muscle relaxation and mild hypoxaemia during monitoring the anaesthesia was rapidly and completely reversed by naltrexone hydrochloride (30 mg/mg of A3080) and atipamezole hydrochloride (5 mg/mg of MED) given intramuscularly There was no mortality or morbidity associated with this protocol.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalJournal of the South African Veterinary Association
Issue number1
StatePublished - Mar 2005
Externally publishedYes


  • A3080
  • Anaesthesia
  • Atipamezole hydrochloride
  • Ketamine hydrochloride
  • Medetomidine hydrochloride
  • Naltrexone hydrochloride
  • Nyala
  • Thiafentanil
  • Tragelaphus angasi

ASJC Scopus subject areas

  • veterinary(all)


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