TY - JOUR
T1 - An umbrella review of the evidence associating diet and cancer risk at 11 anatomical sites
AU - Papadimitriou, Nikos
AU - Markozannes, Georgios
AU - Kanellopoulou, Afroditi
AU - Critselis, Elena
AU - Alhardan, Sumayah
AU - Karafousia, Vaia
AU - Kasimis, John C.
AU - Katsaraki, Chrysavgi
AU - Papadopoulou, Areti
AU - Zografou, Maria
AU - Lopez, David S.
AU - Chan, Doris S.M.
AU - Kyrgiou, Maria
AU - Ntzani, Evangelia
AU - Cross, Amanda J.
AU - Marrone, Michael T.
AU - Platz, Elizabeth A.
AU - Gunter, Marc J.
AU - Tsilidis, Konstantinos K.
N1 - Funding Information:
The authors wish to thank Dr. Teresa Norat and the WCRF CUP team at Imperial College London for their continued efforts in conducting the CUP meta-analyses and their support in retrieving this data for the current umbrella review. The authors wish to thank Dr. Antonia Vlahou, Staff Research Scientist - Professor Level, of the Proteomics Facility at the Biomedical Research Foundation of the Academy of Athens for funding support of E.C. and C.K. This work was supported by the World Cancer Research Fund International Regular Grant Programme (WCRF 2014/1180 to K.K.T.). E.C. was supported by the Hellenic State Scholarships Foundation scholarship funded under the Action “Reinforcement of Postdoctoral Researchers” of the Framework Programme “Development of Human Resources, Education, and Life-long Learning”, with priority actions 6, 8, and 9, and co-funded by the European Social Fund and the Hellenic Republic. E.A.P. and M.T.M. were supported by the US NIH (P30 CA006973, T32 CA009314). The study sponsor had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the article; and decision to submit the article for publication.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - There is evidence that diet and nutrition are modifiable risk factors for several cancers, but associations may be flawed due to inherent biases. Nutritional epidemiology studies have largely relied on a single assessment of diet using food frequency questionnaires. We conduct an umbrella review of meta-analyses of observational studies to evaluate the strength and validity of the evidence for the association between food/nutrient intake and risk of developing or dying from 11 primary cancers. It is estimated that only few single food/nutrient and cancer associations are supported by strong or highly suggestive meta-analytic evidence, and future similar research is unlikely to change this evidence. Alcohol consumption is positively associated with risk of postmenopausal breast, colorectal, esophageal, head & neck and liver cancer. Consumption of dairy products, milk, calcium and wholegrains are inversely associated with colorectal cancer risk. Coffee consumption is inversely associated with risk of liver cancer and skin basal cell carcinoma.
AB - There is evidence that diet and nutrition are modifiable risk factors for several cancers, but associations may be flawed due to inherent biases. Nutritional epidemiology studies have largely relied on a single assessment of diet using food frequency questionnaires. We conduct an umbrella review of meta-analyses of observational studies to evaluate the strength and validity of the evidence for the association between food/nutrient intake and risk of developing or dying from 11 primary cancers. It is estimated that only few single food/nutrient and cancer associations are supported by strong or highly suggestive meta-analytic evidence, and future similar research is unlikely to change this evidence. Alcohol consumption is positively associated with risk of postmenopausal breast, colorectal, esophageal, head & neck and liver cancer. Consumption of dairy products, milk, calcium and wholegrains are inversely associated with colorectal cancer risk. Coffee consumption is inversely associated with risk of liver cancer and skin basal cell carcinoma.
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U2 - 10.1038/s41467-021-24861-8
DO - 10.1038/s41467-021-24861-8
M3 - Article
C2 - 34321471
AN - SCOPUS:85111523358
SN - 2041-1723
VL - 12
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 4579
ER -