TY - JOUR
T1 - An ultrastructural study of ovarian perifollicular capillaries in the indomethacin-treated rabbit
AU - Okuda, Y.
AU - Okamura, H.
AU - Kanzaki, H.
AU - Fujii, S.
AU - Takenaka, A.
AU - Wallach, E. E.
N1 - Funding Information:
Received February 2, 1982; revised and accepted September 1, 1982. *Supported in part by NIH grant HD-05948 and the Duberstein Foundation. tDepartment of Obstetrics and Gynecology, Kyoto University Faculty of Medicine, Kyoto, Japan. *Reprint requests: Hitoshi Okamura, M.D., Department of Obstetrics and Gynecology, Kyoto University Faculty of Medicine, 54 Kawaharacho, Sakyo-ku, Kyoto, Japan. §Department of Obstetrics and Gynecology, Pennsylvania Hospital and University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19107.
PY - 1983
Y1 - 1983
N2 - The perifollicular capillaries of the rabbit ovary were observed by light and electron microscopy following administration of human chorionic gonadotropin (hCG) and indomethacin (IM). Fenestrations and interendothelial gaps were not observed at 4, 10, or 12 hours, at which times carbon particles were confined to capillary lumina. By 24 hours, dilated capillaries were noted among granulosa cells and theca. In the theca, interendothelial gaps permeable to carbon particles were observed. At 48 hours, ribosome-rich, newly developed capillaries were noted. Many collagen fibrils were observed in the tunica albuginea and theca externa in hCG/IM-treated rabbits in contrast to those treated with hCG alone. Ovarian prostaglandins normally produced in response to gonadotropins may be responsible for alterations in perifollicular capillaries and degradation of collagen in the follicular wall, changes considered essential for ovulation.
AB - The perifollicular capillaries of the rabbit ovary were observed by light and electron microscopy following administration of human chorionic gonadotropin (hCG) and indomethacin (IM). Fenestrations and interendothelial gaps were not observed at 4, 10, or 12 hours, at which times carbon particles were confined to capillary lumina. By 24 hours, dilated capillaries were noted among granulosa cells and theca. In the theca, interendothelial gaps permeable to carbon particles were observed. At 48 hours, ribosome-rich, newly developed capillaries were noted. Many collagen fibrils were observed in the tunica albuginea and theca externa in hCG/IM-treated rabbits in contrast to those treated with hCG alone. Ovarian prostaglandins normally produced in response to gonadotropins may be responsible for alterations in perifollicular capillaries and degradation of collagen in the follicular wall, changes considered essential for ovulation.
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U2 - 10.1016/s0015-0282(16)46763-4
DO - 10.1016/s0015-0282(16)46763-4
M3 - Article
C2 - 6848395
AN - SCOPUS:0020666686
SN - 0309-1708
VL - 39
SP - 85
EP - 92
JO - Advances in Water Resources
JF - Advances in Water Resources
IS - 1
ER -