An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

Sarah E. Beck, Suzanne E. Queen, Kelly A. Metcalf Pate, Lisa M. Mangus, Celina M. Abreu, Lucio Gama, Kenneth W. Witwer, Robert J. Adams, M. Christine Zink, Janice E. Clements, Joseph L. Mankowski

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Simian immunodeficiency virus (SIV) infection of pigtailed macaques is a highly representative and well-characterized animal model for HIV neuropathogenesis studies that provides an excellent opportunity to study and develop prognostic markers of HIV-associated neurocognitive disorders (HAND) for HIV-infected individuals. SIV studies can be performed in a controlled setting that enhances reproducibility and offers high-translational value. Similar to observations in HIV-infected patients receiving antiretroviral therapy (ART), ongoing neurodegeneration and inflammation are present in SIV-infected pigtailed macaques treated with suppressive ART. By developing quantitative viral outgrowth assays that measure both CD4+ T cells and macrophages harboring replication competent SIVas well as a highly sensitive mouse-based viral outgrowth assay, we have positioned the SIV/pigtailed macaque model to advance our understanding of latent cellular reservoirs, including potential CNS reservoirs, to promote HIV cure. In addition to contributing to our understanding of the pathogenesis of HAND, the SIV/ pigtailed macaque model also provides an excellent opportunity to test innovative approaches to eliminate the latent HIV reservoir in the brain.

Original languageEnglish (US)
Pages (from-to)204-212
Number of pages9
JournalJournal of neurovirology
Issue number2
StatePublished - Oct 3 2018


  • Anti-retroviral therapy
  • HAND
  • HIV
  • Latent CNS reservoirs
  • Macaque
  • Macrophage
  • QVOA
  • SIV

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology


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