An outbreak of rotavirus-associated neonatal necrotizing enterocolitis

Harley A. Rotbart; Myron J. Levin; Robert H. Yolken; David K. Manchester; James Jantzen

doi:10.1016/S0022-3476(83)80427-2

An outbreak of rotavirus-associated neonatal necrotizing enterocolitis

Harley A. Rotbart, Myron J. Levin, Robert H. Yolken, David K. Manchester, James Jantzen

School of Medicine

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

An outbreak of necrotizing enterocolitis and hemorrhagic gastroenteritis occurred in two nurseries during 25 days in August 1982. Eleven of the 40 patients in these nurseries during that time developed disease (attack rate 27.5%). In seven of the 10 patients with gastrointestinal disease, stool samples tested for human rotavirus were positive by ELISA, whereas in 20 unaffected infants, no stools tested demonstrated HRV (P=0.0001). Eleven staff members had serologic evidence of recent HRV infection. Comparison of risk factors traditionally associated with the development of NEC between the affected and unaffected infants revealed no significant differences. Rotavirus infection was the only finding that was highly correlated with this epidemic.

Original language	English (US)
Pages (from-to)	454-459
Number of pages	6
Journal	The Journal of pediatrics
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/S0022-3476(83)80427-2
State	Published - Sep 1983

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1016/S0022-3476(83)80427-2

Cite this

@article{58cbb3fdac6443fca2f52e4dda4e1b72,

title = "An outbreak of rotavirus-associated neonatal necrotizing enterocolitis",

abstract = "An outbreak of necrotizing enterocolitis and hemorrhagic gastroenteritis occurred in two nurseries during 25 days in August 1982. Eleven of the 40 patients in these nurseries during that time developed disease (attack rate 27.5%). In seven of the 10 patients with gastrointestinal disease, stool samples tested for human rotavirus were positive by ELISA, whereas in 20 unaffected infants, no stools tested demonstrated HRV (P=0.0001). Eleven staff members had serologic evidence of recent HRV infection. Comparison of risk factors traditionally associated with the development of NEC between the affected and unaffected infants revealed no significant differences. Rotavirus infection was the only finding that was highly correlated with this epidemic.",

author = "Rotbart, {Harley A.} and Levin, {Myron J.} and Yolken, {Robert H.} and Manchester, {David K.} and James Jantzen",

note = "Funding Information: From the Department of Pediatrics, Sections of Pediatric Infectious Diseases and Neonatology, University of Colorado School of Medicine; Division of Pediatric Infectious Diseases, Johns Hopkins Medical School; and Indiana University School of Medicine. Supported by Grants BRSG-05357, Biomedical Research Program, Division of Research Resources, and RO1-AI-17604 and NO I-AI-23660, National Institutes of'Health. Presented in part at the Annual Meeting of the Society for Pediatric Research, Washington, D.C.. May 4. 1983. Reprint requests: Harley A. Rotbart, M.D.. Pediatric Infectious Diseases, University of Colorado School of Medicine, Campus Box C-227, Denver, CO 80262.",

year = "1983",

month = sep,

doi = "10.1016/S0022-3476(83)80427-2",

language = "English (US)",

volume = "103",

pages = "454--459",

journal = "The Journal of pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

number = "3",

}

TY - JOUR

T1 - An outbreak of rotavirus-associated neonatal necrotizing enterocolitis

AU - Rotbart, Harley A.

AU - Levin, Myron J.

AU - Yolken, Robert H.

AU - Manchester, David K.

AU - Jantzen, James

N1 - Funding Information: From the Department of Pediatrics, Sections of Pediatric Infectious Diseases and Neonatology, University of Colorado School of Medicine; Division of Pediatric Infectious Diseases, Johns Hopkins Medical School; and Indiana University School of Medicine. Supported by Grants BRSG-05357, Biomedical Research Program, Division of Research Resources, and RO1-AI-17604 and NO I-AI-23660, National Institutes of'Health. Presented in part at the Annual Meeting of the Society for Pediatric Research, Washington, D.C.. May 4. 1983. Reprint requests: Harley A. Rotbart, M.D.. Pediatric Infectious Diseases, University of Colorado School of Medicine, Campus Box C-227, Denver, CO 80262.

PY - 1983/9

Y1 - 1983/9

N2 - An outbreak of necrotizing enterocolitis and hemorrhagic gastroenteritis occurred in two nurseries during 25 days in August 1982. Eleven of the 40 patients in these nurseries during that time developed disease (attack rate 27.5%). In seven of the 10 patients with gastrointestinal disease, stool samples tested for human rotavirus were positive by ELISA, whereas in 20 unaffected infants, no stools tested demonstrated HRV (P=0.0001). Eleven staff members had serologic evidence of recent HRV infection. Comparison of risk factors traditionally associated with the development of NEC between the affected and unaffected infants revealed no significant differences. Rotavirus infection was the only finding that was highly correlated with this epidemic.

AB - An outbreak of necrotizing enterocolitis and hemorrhagic gastroenteritis occurred in two nurseries during 25 days in August 1982. Eleven of the 40 patients in these nurseries during that time developed disease (attack rate 27.5%). In seven of the 10 patients with gastrointestinal disease, stool samples tested for human rotavirus were positive by ELISA, whereas in 20 unaffected infants, no stools tested demonstrated HRV (P=0.0001). Eleven staff members had serologic evidence of recent HRV infection. Comparison of risk factors traditionally associated with the development of NEC between the affected and unaffected infants revealed no significant differences. Rotavirus infection was the only finding that was highly correlated with this epidemic.

UR - http://www.scopus.com/inward/record.url?scp=0020506147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020506147&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(83)80427-2

DO - 10.1016/S0022-3476(83)80427-2

M3 - Article

C2 - 6310072

AN - SCOPUS:0020506147

SN - 0022-3476

VL - 103

SP - 454

EP - 459

JO - The Journal of pediatrics

JF - The Journal of pediatrics

IS - 3

ER -

An outbreak of rotavirus-associated neonatal necrotizing enterocolitis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this