An outbreak of rotavirus-associated neonatal necrotizing enterocolitis

Harley A. Rotbart, Myron J. Levin, Robert H. Yolken, David K. Manchester, James Jantzen

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


An outbreak of necrotizing enterocolitis and hemorrhagic gastroenteritis occurred in two nurseries during 25 days in August 1982. Eleven of the 40 patients in these nurseries during that time developed disease (attack rate 27.5%). In seven of the 10 patients with gastrointestinal disease, stool samples tested for human rotavirus were positive by ELISA, whereas in 20 unaffected infants, no stools tested demonstrated HRV (P=0.0001). Eleven staff members had serologic evidence of recent HRV infection. Comparison of risk factors traditionally associated with the development of NEC between the affected and unaffected infants revealed no significant differences. Rotavirus infection was the only finding that was highly correlated with this epidemic.

Original languageEnglish (US)
Pages (from-to)454-459
Number of pages6
JournalThe Journal of pediatrics
Issue number3
StatePublished - Sep 1983

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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