@article{eb1857d90c794231a6cc36bf2912cf11,
title = "An outbreak of hepatitis A among cancer patients treated with interleukin-2 and lymphokine-activated killer cells",
abstract = "An outbreak of hepatitis A virus (HAV) infection occurred among cancer patients treated with interleukin-2 (IL-2) and lymphokine-activated killer (LAK) cells between July and September 1986 at six different clinical centers. Among 85 patients tested serologically for recent HAV infection, 22 (39%) of 56 susceptible patients developed acute HAV infection. Only exposure to LAK cells cultured in medium containing human serum from two specific manufactured pools was associated with HAV infection. Attack rates were 85% among patients exposed to pool X, 62% in patients exposed to pool Y, and 50% in those exposed to both pools, compared with none among the 24 susceptible persons exposed to other serum pools (P<.001). The serum used in production of LAK cell medium was obtained from multiple paid donors. Twenty persons donated plasma to both serum pools X and Y. Although none of 12 donors tested had evidence of recent HAVinfection, it is likely that an asymptomatic plasma donor viremic for HAV contaminated both serum pools and the LAK cell medium made from it.",
author = "Weisfuse, {Isaac B.} and Graham, {David J.} and Marcia Will and David Parkinson and Snydman, {David R.} and Michael Atkins and Karron, {Ruth A.} and Stephen Feinstone and Rayner, {Anthony A.} and Fisher, {Richard I.} and Mills, {Bonnie J.} and Dutcher, {Janice R.} and Weiss, {Geoffrey R.} and Alice Glover and Kuritsky, {Joel N.} and Hadler, {Stephen C.}",
note = "Funding Information: From the Hepatitis Branch, Division of Viral Diseases, Center for Infectious Diseases, and the Epidemiology Program Office, Centers for Disease Control, Atlanta, Georgia; the Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, and the Laboratory ofInfectious Diseases, National Institute ofAllergy and Infectious Diseases, National Institutes ofHealth, Bethesda, Maryland; the Departments of Medicine, Pathology, and Epidemiology, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts; Cancer Research Institute at the University of California, San Francisco, and City ofHope Cancer Research Center, Duarte, California; Loyola University Medical Center, Marywood, Illinois; Albert Einstein Cancer Center, Bronx, New lbrk; and University of Texas, San Antonio",
year = "1990",
month = apr,
doi = "10.1093/infdis/161.4.647",
language = "English (US)",
volume = "161",
pages = "647--652",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",
}