An optimized radiosynthesis of [18F]DK222, a PET radiotracer for imaging PD-L1

Daniel P. Holt; Dhiraj Kumar; Sridhar Nimmagadda; Robert F. Dannals

doi:10.1002/jlcr.4012

An optimized radiosynthesis of [¹⁸F]DK222, a PET radiotracer for imaging PD-L1

Daniel P. Holt, Dhiraj Kumar, Sridhar Nimmagadda, Robert F. Dannals

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A radiochemical synthesis of [¹⁸F]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).

Original language	English (US)
Pages (from-to)	47-54
Number of pages	8
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	66
Issue number	2
DOIs	https://doi.org/10.1002/jlcr.4012
State	Published - Feb 2023

Keywords

AlF
PD-L1
PET
fluorine-18
radiochemistry

ASJC Scopus subject areas

Drug Discovery
Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.4012

Cite this

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title = "An optimized radiosynthesis of [18F]DK222, a PET radiotracer for imaging PD-L1",

abstract = "A radiochemical synthesis of [18F]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).",

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AU - Dannals, Robert F.

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