TY - JOUR
T1 - An odorant-binding protein required for suppression of sweet taste by bitter chemicals
AU - Jeong, YongTaek
AU - Shim, Jaewon
AU - Oh, SoRa
AU - Yoon, HongIn
AU - Kim, ChulHoon
AU - Moon, SeokJun
AU - Montell, Craig
PY - 2013/8/21
Y1 - 2013/8/21
N2 - Animals often must decide whether or not to consume a diet that contains competing attractive and aversive compounds. Here, using the fruit fly, Drosophila melanogaster, we describe a mechanism that influences this decision. Addition of bitter compounds to sucrose suppressed feeding behavior, and this inhibition depended on an odorant-binding protein (OBP) termed OBP49a. In wild-type flies, bitter compounds suppressed sucrose-induced action potentials, and the inhibition was impaired in Obp49a mutants. However, loss of OBP49a did not affect action potentials in sugar- or bitter-activated gustatory receptor neurons (GRNs) when the GRNs were presented with just one type of tastant. OBP49a was expressed in accessory cells and acted non-cell-autonomously to attenuate nerve firings in sugar-activated GRNs when bitter compounds were combined with sucrose. These findings demonstrate an unexpected role for an OBP in taste andidentify a molecular player involved in the integration of opposing attractive and aversive gustatory inputs
AB - Animals often must decide whether or not to consume a diet that contains competing attractive and aversive compounds. Here, using the fruit fly, Drosophila melanogaster, we describe a mechanism that influences this decision. Addition of bitter compounds to sucrose suppressed feeding behavior, and this inhibition depended on an odorant-binding protein (OBP) termed OBP49a. In wild-type flies, bitter compounds suppressed sucrose-induced action potentials, and the inhibition was impaired in Obp49a mutants. However, loss of OBP49a did not affect action potentials in sugar- or bitter-activated gustatory receptor neurons (GRNs) when the GRNs were presented with just one type of tastant. OBP49a was expressed in accessory cells and acted non-cell-autonomously to attenuate nerve firings in sugar-activated GRNs when bitter compounds were combined with sucrose. These findings demonstrate an unexpected role for an OBP in taste andidentify a molecular player involved in the integration of opposing attractive and aversive gustatory inputs
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U2 - 10.1016/j.neuron.2013.06.025
DO - 10.1016/j.neuron.2013.06.025
M3 - Article
C2 - 23972598
AN - SCOPUS:84882638577
SN - 0896-6273
VL - 79
SP - 725
EP - 737
JO - Neuron
JF - Neuron
IS - 4
ER -