An MRI study of amygdala in schizophrenia and psychotic bipolar disorder

Pamela Belmonte Mahon, Haley Eldridge, Britni Crocker, Lisa Notes, Holly Gindes, Elizabeth Postell, Stacey King, James B. Potash, J. Tilak Ratnanather, Patrick E. Barta

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had smaller amygdala compared with patients with psychotic bipolar disorder (p = 0.014). These results suggest that change in volume of amygdala may represent a morphologic feature distinguishing psychotic bipolar disorder from schizophrenia.

Original languageEnglish (US)
Pages (from-to)188-191
Number of pages4
JournalSchizophrenia Research
Issue number2-3
StatePublished - Jul 2012


  • Amygdala
  • MRI
  • Psychotic bipolar disorder
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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