An isotope release cytotoxicity assay applicable to human tumors: The use of 11 indium

P. Frost; R. Wiltrout; Z. Maciorowski; N. R. Rose

doi:10.1159/000225200

An isotope release cytotoxicity assay applicable to human tumors: The use of 11 indium

P. Frost, R. Wiltrout, Z. Maciorowski, N. R. Rose

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We have demonstrated that human tumors can be labelled efficiently with the indium-oxine chelate. Subsequently, this isotope can be released by cytotoxic lymphoid cells. Both natural and induced cytotoxicity can be demonstrated utilizing this isotope release method. Because of the slow spontaneous release of 1 indium and its efficient labelling of human tumor cells, this isotope release assay can be utilized in long-term cytotoxic assays in the study of human tumor immunology.

Original language	English (US)
Pages (from-to)	102-104
Number of pages	3
Journal	Oncology (Switzerland)
Volume	34
Issue number	3
DOIs	https://doi.org/10.1159/000225200
State	Published - 1977

Keywords

Cytotoxicity-Human tumors-111 Indium

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1159/000225200

Cite this

@article{5d5016e7d7ef4f25bdeab0830d246352,

title = "An isotope release cytotoxicity assay applicable to human tumors: The use of 11 indium",

abstract = "We have demonstrated that human tumors can be labelled efficiently with the indium-oxine chelate. Subsequently, this isotope can be released by cytotoxic lymphoid cells. Both natural and induced cytotoxicity can be demonstrated utilizing this isotope release method. Because of the slow spontaneous release of 1 indium and its efficient labelling of human tumor cells, this isotope release assay can be utilized in long-term cytotoxic assays in the study of human tumor immunology.",

keywords = "Cytotoxicity-Human tumors-111 Indium",

author = "P. Frost and R. Wiltrout and Z. Maciorowski and Rose, {N. R.}",

year = "1977",

doi = "10.1159/000225200",

language = "English (US)",

volume = "34",

pages = "102--104",

journal = "Oncology (Switzerland)",

issn = "0030-2414",

publisher = "UBM Medica Healthcare Publications",

number = "3",

}

TY - JOUR

T1 - An isotope release cytotoxicity assay applicable to human tumors

T2 - The use of 11 indium

AU - Frost, P.

AU - Wiltrout, R.

AU - Maciorowski, Z.

AU - Rose, N. R.

PY - 1977

Y1 - 1977

N2 - We have demonstrated that human tumors can be labelled efficiently with the indium-oxine chelate. Subsequently, this isotope can be released by cytotoxic lymphoid cells. Both natural and induced cytotoxicity can be demonstrated utilizing this isotope release method. Because of the slow spontaneous release of 1 indium and its efficient labelling of human tumor cells, this isotope release assay can be utilized in long-term cytotoxic assays in the study of human tumor immunology.

AB - We have demonstrated that human tumors can be labelled efficiently with the indium-oxine chelate. Subsequently, this isotope can be released by cytotoxic lymphoid cells. Both natural and induced cytotoxicity can be demonstrated utilizing this isotope release method. Because of the slow spontaneous release of 1 indium and its efficient labelling of human tumor cells, this isotope release assay can be utilized in long-term cytotoxic assays in the study of human tumor immunology.

KW - Cytotoxicity-Human tumors-111 Indium

UR - http://www.scopus.com/inward/record.url?scp=0017708914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017708914&partnerID=8YFLogxK

U2 - 10.1159/000225200

DO - 10.1159/000225200

M3 - Article

C2 - 917438

AN - SCOPUS:0017708914

SN - 0030-2414

VL - 34

SP - 102

EP - 104

JO - Oncology (Switzerland)

JF - Oncology (Switzerland)

IS - 3

ER -

An isotope release cytotoxicity assay applicable to human tumors: The use of 11 indium

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this