TY - JOUR
T1 - An investigation of the relationship between antioxidant vitamin intake and coronary heart disease in men and women using logistic regression analysis
AU - Todd, Susan
AU - Woodward, Mark
AU - Bolton-Smith, Caroline
N1 - Funding Information:
Acknowledgements-The SHHS was funded predominantly by the Scottish Home and Health Department. ST. thanks the Science and Engineering Research council for financial support during the period of her research. Any views expressed here are solely those of the authors and not necessarily of the funding bodies.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1995/2
Y1 - 1995/2
N2 - Antioxidant vitamin intake (C,E and carotene) is assessed from a food frequency questionnaire applied to 10,359 middle-aged men and women participating in the Scottish Heart Health Study. Logistic regression analysis is then used to quantify the relationship between antioxidant vitamin consumption and prevalent coronary heart disease (CHD), analysing diagnosed and undiagnosed cases separately. For men, there is a protective effect of all three antioxidants, before and after adjustment for a comprehensive set of confounding variables. For women the picture is less clear, only vitamin C is negatively associated with CHD, but the effect is removed by adjustment. The logistic regression model is also used to determine classification rules for deciding whether or not an individual has CHD. The classification error rates using the antioxidants are found to be very similar to those found using smoking, blood pressure and serum total cholesterol as classification variables. Significant interactions are found for the antioxidants with smoking, cholesterol and age. It is concluded that antioxidant vitamin intake protects against CHD for men. Logistic regression analysis is compared with discriminant analysis, and is found to have important advantages as an epidemiological tool.
AB - Antioxidant vitamin intake (C,E and carotene) is assessed from a food frequency questionnaire applied to 10,359 middle-aged men and women participating in the Scottish Heart Health Study. Logistic regression analysis is then used to quantify the relationship between antioxidant vitamin consumption and prevalent coronary heart disease (CHD), analysing diagnosed and undiagnosed cases separately. For men, there is a protective effect of all three antioxidants, before and after adjustment for a comprehensive set of confounding variables. For women the picture is less clear, only vitamin C is negatively associated with CHD, but the effect is removed by adjustment. The logistic regression model is also used to determine classification rules for deciding whether or not an individual has CHD. The classification error rates using the antioxidants are found to be very similar to those found using smoking, blood pressure and serum total cholesterol as classification variables. Significant interactions are found for the antioxidants with smoking, cholesterol and age. It is concluded that antioxidant vitamin intake protects against CHD for men. Logistic regression analysis is compared with discriminant analysis, and is found to have important advantages as an epidemiological tool.
KW - Antioxidant vitamins
KW - Blood pressure
KW - Cholesterol
KW - Coronary heart disease risk factors
KW - Food frequency questionnaire
KW - Smoking
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U2 - 10.1016/0895-4356(94)00178-S
DO - 10.1016/0895-4356(94)00178-S
M3 - Article
C2 - 7869077
AN - SCOPUS:0028937214
SN - 0895-4356
VL - 48
SP - 307
EP - 316
JO - Journal of Chronic Diseases
JF - Journal of Chronic Diseases
IS - 2
ER -