TY - GEN
T1 - An integrated micropost-microgroove device for biomechanical characterization of cardiomyocytes
AU - Kim, Peter
AU - Choi, Young Soo
AU - Lee, Dong Weon
AU - Kim, Deok Ho
N1 - Publisher Copyright:
© 15CBMS-0001.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - Cells of myocardium exhibit a high anisotropy, action potential conduction velocity, and coordinated contractile behavior in conjunction to extracellular matrix of myocardium. Understanding the mechanisms of native cardiomyocyte contraction requires the development of tool sets that can both recapitulate in vivo microenvironment for faithful model generation and measure cellular traction forces. However, there has been a lack of techniques that integrate biomimetic design and traction force measurement components to study cardiac contraction. Here, we describe a system that uses an array of microposts to sense traction force applied by contracting cells adhered on microgrooves that mimic extracellular matrix (ECM) of cardiac myocardium.
AB - Cells of myocardium exhibit a high anisotropy, action potential conduction velocity, and coordinated contractile behavior in conjunction to extracellular matrix of myocardium. Understanding the mechanisms of native cardiomyocyte contraction requires the development of tool sets that can both recapitulate in vivo microenvironment for faithful model generation and measure cellular traction forces. However, there has been a lack of techniques that integrate biomimetic design and traction force measurement components to study cardiac contraction. Here, we describe a system that uses an array of microposts to sense traction force applied by contracting cells adhered on microgrooves that mimic extracellular matrix (ECM) of cardiac myocardium.
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M3 - Conference contribution
AN - SCOPUS:84983289162
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 561
EP - 564
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -