An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Karen I. Zeller; Anil G. Jegga; Bruce J. Aronow; Kathryn A. O'Donnell; Chi V. Dang

doi:10.1186/gb-2003-4-10-r69

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Karen I. Zeller, Anil G. Jegga, Bruce J. Aronow, Kathryn A. O'Donnell, Chi V. Dang

School of Medicine

Research output: Contribution to journal › Article › peer-review

372 Scopus citations

Abstract

We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

Original language	English (US)
Article number	R69
Journal	Genome biology
Volume	4
Issue number	10
DOIs	https://doi.org/10.1186/gb-2003-4-10-r69
State	Published - Oct 2003

Keywords

Chromatin Immunoprecipitation
DDX18 Gene
Direct Target Gene
Phylogenetic Footprinting
Putative Target Gene

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Cell Biology

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10.1186/gb-2003-4-10-r69

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title = "An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets",

abstract = "We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.",

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author = "Zeller, {Karen I.} and Jegga, {Anil G.} and Aronow, {Bruce J.} and O'Donnell, {Kathryn A.} and Dang, {Chi V.}",

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AU - O'Donnell, Kathryn A.

AU - Dang, Chi V.

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KW - Phylogenetic Footprinting

KW - Putative Target Gene

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An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Abstract

Keywords

ASJC Scopus subject areas

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