An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Karen I. Zeller, Anil G. Jegga, Bruce J. Aronow, Kathryn A. O'Donnell, Chi V. Dang

Research output: Contribution to journalArticlepeer-review

372 Scopus citations

Abstract

We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

Original languageEnglish (US)
Article numberR69
JournalGenome biology
Volume4
Issue number10
DOIs
StatePublished - Oct 2003

Keywords

  • Chromatin Immunoprecipitation
  • DDX18 Gene
  • Direct Target Gene
  • Phylogenetic Footprinting
  • Putative Target Gene

ASJC Scopus subject areas

  • Genetics
  • Ecology, Evolution, Behavior and Systematics
  • Cell Biology

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