An Immunocompetent Patient with High Neutralizing Antibody Titers Who Shed COVID-19 Virus for 169 days — China, 2020

Li Li; Siqi Li; Yang Pan; Ling Qin; Siyuan Yang; Dawei Tan; Yaling Hu; Maria Deloria Knoll; Xiaoli Wang; Linghang Wang; Quanyi Wang

doi:10.46234/ccdcw2021.163

An Immunocompetent Patient with High Neutralizing Antibody Titers Who Shed COVID-19 Virus for 169 days — China, 2020

Li Li, Siqi Li, Yang Pan, Ling Qin, Siyuan Yang, Dawei Tan, Yaling Hu, Maria Deloria Knoll, Xiaoli Wang, Linghang Wang, Quanyi Wang

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Few reports are available about prolonged shedding of coronavirus disease (COVID-19) virus, also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by immunocompetent patients. We report a case of an infected, immunocompetent person with 169 days of COVID-19 virus shedding during which time he had two brief periods when he tested negative for COVID-19 followed by again testing positive. We describe relevant clinical, immunological, and genomic features. We found that continuous and prolonged viral replication and infectivity existed in an immunocompetent COVID-19 patient, despite having high neutralizing antibody titers.

Original language	English (US)
Pages (from-to)	688-697
Number of pages	10
Journal	China CDC Weekly
Volume	3
Issue number	32
DOIs	https://doi.org/10.46234/ccdcw2021.163
State	Published - 2021

ASJC Scopus subject areas

Epidemiology
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.46234/ccdcw2021.163

Cite this

@article{eb0825d41c744328b5c2a1deabd3bac1,

title = "An Immunocompetent Patient with High Neutralizing Antibody Titers Who Shed COVID-19 Virus for 169 days — China, 2020",

abstract = "Few reports are available about prolonged shedding of coronavirus disease (COVID-19) virus, also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by immunocompetent patients. We report a case of an infected, immunocompetent person with 169 days of COVID-19 virus shedding during which time he had two brief periods when he tested negative for COVID-19 followed by again testing positive. We describe relevant clinical, immunological, and genomic features. We found that continuous and prolonged viral replication and infectivity existed in an immunocompetent COVID-19 patient, despite having high neutralizing antibody titers.",

author = "Li Li and Siqi Li and Yang Pan and Ling Qin and Siyuan Yang and Dawei Tan and Yaling Hu and Knoll, {Maria Deloria} and Xiaoli Wang and Linghang Wang and Quanyi Wang",

note = "Funding Information: Funding: The National Key Research and Development Program of China (2020YFA0707600); the Scientific Research Project of Youan Hospital, CCMU, 2020 (BJYAYY-2020YC-01); and the National Key Research and Development Program of China (2020YFC0840800). Publisher Copyright: {\textcopyright} 2021, Chinese Center for Disease Control and Prevention.",

year = "2021",

doi = "10.46234/ccdcw2021.163",

language = "English (US)",

volume = "3",

pages = "688--697",

journal = "China CDC Weekly",

issn = "2096-7071",

publisher = "Chinese Center for Disease Control and Prevention",

number = "32",

}

TY - JOUR

T1 - An Immunocompetent Patient with High Neutralizing Antibody Titers Who Shed COVID-19 Virus for 169 days — China, 2020

AU - Li, Li

AU - Li, Siqi

AU - Pan, Yang

AU - Qin, Ling

AU - Yang, Siyuan

AU - Tan, Dawei

AU - Hu, Yaling

AU - Knoll, Maria Deloria

AU - Wang, Xiaoli

AU - Wang, Linghang

AU - Wang, Quanyi

N1 - Funding Information: Funding: The National Key Research and Development Program of China (2020YFA0707600); the Scientific Research Project of Youan Hospital, CCMU, 2020 (BJYAYY-2020YC-01); and the National Key Research and Development Program of China (2020YFC0840800). Publisher Copyright: © 2021, Chinese Center for Disease Control and Prevention.

PY - 2021

Y1 - 2021

N2 - Few reports are available about prolonged shedding of coronavirus disease (COVID-19) virus, also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by immunocompetent patients. We report a case of an infected, immunocompetent person with 169 days of COVID-19 virus shedding during which time he had two brief periods when he tested negative for COVID-19 followed by again testing positive. We describe relevant clinical, immunological, and genomic features. We found that continuous and prolonged viral replication and infectivity existed in an immunocompetent COVID-19 patient, despite having high neutralizing antibody titers.

AB - Few reports are available about prolonged shedding of coronavirus disease (COVID-19) virus, also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by immunocompetent patients. We report a case of an infected, immunocompetent person with 169 days of COVID-19 virus shedding during which time he had two brief periods when he tested negative for COVID-19 followed by again testing positive. We describe relevant clinical, immunological, and genomic features. We found that continuous and prolonged viral replication and infectivity existed in an immunocompetent COVID-19 patient, despite having high neutralizing antibody titers.

UR - http://www.scopus.com/inward/record.url?scp=85130423651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85130423651&partnerID=8YFLogxK

U2 - 10.46234/ccdcw2021.163

DO - 10.46234/ccdcw2021.163

M3 - Article

C2 - 34594968

AN - SCOPUS:85130423651

SN - 2096-7071

VL - 3

SP - 688

EP - 697

JO - China CDC Weekly

JF - China CDC Weekly

IS - 32

ER -

An Immunocompetent Patient with High Neutralizing Antibody Titers Who Shed COVID-19 Virus for 169 days — China, 2020

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this