An explanation for the localization of herpes simplex encephalitis?

Larry E. Davis, Richard T. Johnson

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


Herpes simplex virus encephalitis tends to localize to the temporal and orbitofrontal lobes, giving characteristic clinical and pathological findings. Since the virus remains latent in the trigeminal ganglia, we postulate that this localization may be explained by reactivated virus spreading along the fifth nerve fibers, which innervate basal meninges of the anterior and middle fossae.

Original languageEnglish (US)
Pages (from-to)2-5
Number of pages4
JournalAnnals of neurology
Issue number1
StatePublished - Jan 1979

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'An explanation for the localization of herpes simplex encephalitis?'. Together they form a unique fingerprint.

Cite this