An Exciting Release on TRPM7

Craig Montell

doi:10.1016/j.neuron.2006.10.012

An Exciting Release on TRPM7

Craig Montell

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Following fusion, synaptic vesicles do not always release all of their neurotransmitter. According to one model, neurotransmitters bind to a charged matrix within secretory vesicles, and release requires entry of counterions. In the current issue of Neuron, Krapivinsky et al. demonstrate that TRPM7 is localized to synaptic vesicles and is required for release of the positively charged neurotransmitter acetylcholine. The results raise the possibility that TRPM7 is the enigmatic channel that supplies counterions for neurotransmitter release.

Original language	English (US)
Pages (from-to)	395-397
Number of pages	3
Journal	Neuron
Volume	52
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2006.10.012
State	Published - Nov 9 2006

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2006.10.012

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abstract = "Following fusion, synaptic vesicles do not always release all of their neurotransmitter. According to one model, neurotransmitters bind to a charged matrix within secretory vesicles, and release requires entry of counterions. In the current issue of Neuron, Krapivinsky et al. demonstrate that TRPM7 is localized to synaptic vesicles and is required for release of the positively charged neurotransmitter acetylcholine. The results raise the possibility that TRPM7 is the enigmatic channel that supplies counterions for neurotransmitter release.",

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AB - Following fusion, synaptic vesicles do not always release all of their neurotransmitter. According to one model, neurotransmitters bind to a charged matrix within secretory vesicles, and release requires entry of counterions. In the current issue of Neuron, Krapivinsky et al. demonstrate that TRPM7 is localized to synaptic vesicles and is required for release of the positively charged neurotransmitter acetylcholine. The results raise the possibility that TRPM7 is the enigmatic channel that supplies counterions for neurotransmitter release.

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An Exciting Release on TRPM7

Abstract

ASJC Scopus subject areas

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