An examination of the extent of diastereofacial selection in the reactions of a chiral nitrile oxide with achiral alkenes: A route to β-hydroxy carboxylic acids

Alan P. Kozikowski; Yoshinori Kitagawa; James P. Springer

doi:10.1039/C39830001460

An examination of the extent of diastereofacial selection in the reactions of a chiral nitrile oxide with achiral alkenes: A route to β-hydroxy carboxylic acids

Alan P. Kozikowski, Yoshinori Kitagawa, James P. Springer

School of Medicine

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Abstract

A new synthesis of optically active β-hydroxy carboxylic acids has been developed which is based on the (modest) diastereoselective addition of the chiral nitrile oxide (4) to 1,2-disubstituted alkenes.

Original language	English (US)
Pages (from-to)	1460-1462
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	23
DOIs	https://doi.org/10.1039/C39830001460
State	Published - Jan 1 1983

ASJC Scopus subject areas

Molecular Medicine

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An examination of the extent of diastereofacial selection in the reactions of a chiral nitrile oxide with achiral alkenes: A route to β-hydroxy carboxylic acids. / Kozikowski, Alan P.; Kitagawa, Yoshinori; Springer, James P.
In: Journal of the Chemical Society, Chemical Communications, No. 23, 01.01.1983, p. 1460-1462.

Research output: Contribution to journal › Article › peer-review

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abstract = "A new synthesis of optically active β-hydroxy carboxylic acids has been developed which is based on the (modest) diastereoselective addition of the chiral nitrile oxide (4) to 1,2-disubstituted alkenes.",

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An examination of the extent of diastereofacial selection in the reactions of a chiral nitrile oxide with achiral alkenes: A route to β-hydroxy carboxylic acids

Abstract

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