An evaluation of human protein-protein interaction data in the public domain

Suresh Mathivanan; Balamurugan Periaswamy; T. K B Gandhi; Kumaran Kandasamy; Shubha Suresh; Riaz Mohmood; Y. L. Ramachandra; Akhilesh Pandey

doi:10.1186/1471-2105-7-S5-S19

An evaluation of human protein-protein interaction data in the public domain

Suresh Mathivanan, Balamurugan Periaswamy, T. K B Gandhi, Kumaran Kandasamy, Shubha Suresh, Riaz Mohmood, Y. L. Ramachandra, Akhilesh Pandey

School of Medicine

Research output: Contribution to journal › Article › peer-review

185 Scopus citations

Abstract

Background: Protein-protein interaction (PPI) databases have become a major resource for investigating biological networks and pathways in cells. A number of publicly available repositories for human PPIs are currently available. Each of these databases has their own unique features with a large variation in the type and depth of their annotations. Results: We analyzed the major publicly available primary databases that contain literature curated PPI information for human proteins. This included BIND, DIP, HPRD, IntAct, MINT, MIPS, PDZBase and Reactome databases. The number of binary non-redundant human PPIs ranged from 101 in PDZBase and 346 in MIPS to 11,367 in MINT and 36,617 in HPRD. The number of genes annotated with at least one interactor was 9,427 in HPRD, 4,975 in MINT, 4,614 in IntAct, 3,887 in BIND and

Original language	English (US)
Article number	S19
Journal	BMC Bioinformatics
Volume	7
Issue number	SUPPL.5
DOIs	https://doi.org/10.1186/1471-2105-7-S5-S19
State	Published - Dec 18 2006

ASJC Scopus subject areas

Medicine(all)
Structural Biology
Applied Mathematics
Agricultural and Biological Sciences (miscellaneous)
Artificial Intelligence
Computational Theory and Mathematics
Computer Science Applications
Software

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title = "An evaluation of human protein-protein interaction data in the public domain",

abstract = "Background: Protein-protein interaction (PPI) databases have become a major resource for investigating biological networks and pathways in cells. A number of publicly available repositories for human PPIs are currently available. Each of these databases has their own unique features with a large variation in the type and depth of their annotations. Results: We analyzed the major publicly available primary databases that contain literature curated PPI information for human proteins. This included BIND, DIP, HPRD, IntAct, MINT, MIPS, PDZBase and Reactome databases. The number of binary non-redundant human PPIs ranged from 101 in PDZBase and 346 in MIPS to 11,367 in MINT and 36,617 in HPRD. The number of genes annotated with at least one interactor was 9,427 in HPRD, 4,975 in MINT, 4,614 in IntAct, 3,887 in BIND and ",

author = "Suresh Mathivanan and Balamurugan Periaswamy and Gandhi, {T. K B} and Kumaran Kandasamy and Shubha Suresh and Riaz Mohmood and Ramachandra, {Y. L.} and Akhilesh Pandey",

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AU - Periaswamy, Balamurugan

AU - Gandhi, T. K B

AU - Kandasamy, Kumaran

AU - Suresh, Shubha

AU - Mohmood, Riaz

AU - Ramachandra, Y. L.

AU - Pandey, Akhilesh

PY - 2006/12/18

Y1 - 2006/12/18

N2 - Background: Protein-protein interaction (PPI) databases have become a major resource for investigating biological networks and pathways in cells. A number of publicly available repositories for human PPIs are currently available. Each of these databases has their own unique features with a large variation in the type and depth of their annotations. Results: We analyzed the major publicly available primary databases that contain literature curated PPI information for human proteins. This included BIND, DIP, HPRD, IntAct, MINT, MIPS, PDZBase and Reactome databases. The number of binary non-redundant human PPIs ranged from 101 in PDZBase and 346 in MIPS to 11,367 in MINT and 36,617 in HPRD. The number of genes annotated with at least one interactor was 9,427 in HPRD, 4,975 in MINT, 4,614 in IntAct, 3,887 in BIND and

AB - Background: Protein-protein interaction (PPI) databases have become a major resource for investigating biological networks and pathways in cells. A number of publicly available repositories for human PPIs are currently available. Each of these databases has their own unique features with a large variation in the type and depth of their annotations. Results: We analyzed the major publicly available primary databases that contain literature curated PPI information for human proteins. This included BIND, DIP, HPRD, IntAct, MINT, MIPS, PDZBase and Reactome databases. The number of binary non-redundant human PPIs ranged from 101 in PDZBase and 346 in MIPS to 11,367 in MINT and 36,617 in HPRD. The number of genes annotated with at least one interactor was 9,427 in HPRD, 4,975 in MINT, 4,614 in IntAct, 3,887 in BIND and

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An evaluation of human protein-protein interaction data in the public domain

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