An Elegan(t) Screen for Drug-Microbe Interactions

Alison Vrbanac; Justine W. Debelius; Lingjing Jiang; James T. Morton; Pieter Dorrestein; Rob Knight

doi:10.1016/j.chom.2017.04.014

An Elegan(t) Screen for Drug-Microbe Interactions

Alison Vrbanac, Justine W. Debelius, Lingjing Jiang, James T. Morton, Pieter Dorrestein, Rob Knight

Research output: Contribution to journal › Short survey › peer-review

Abstract

Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C. elegans to infer anticancer drug mechanisms. Through high-throughput screens of drug-microbe-host interactions, García-González et al. (2017) and Scott et al. (2017) determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug metabolism.

Original language	English (US)
Pages (from-to)	555-556
Number of pages	2
Journal	Cell Host and Microbe
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.chom.2017.04.014
State	Published - May 10 2017
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2017.04.014

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abstract = "Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C. elegans to infer anticancer drug mechanisms. Through high-throughput screens of drug-microbe-host interactions, Garc{\'i}a-Gonz{\'a}lez et al. (2017) and Scott et al. (2017) determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug metabolism.",

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AU - Vrbanac, Alison

AU - Debelius, Justine W.

AU - Jiang, Lingjing

AU - Morton, James T.

AU - Dorrestein, Pieter

AU - Knight, Rob

PY - 2017/5/10

Y1 - 2017/5/10

N2 - Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C. elegans to infer anticancer drug mechanisms. Through high-throughput screens of drug-microbe-host interactions, García-González et al. (2017) and Scott et al. (2017) determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug metabolism.

AB - Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C. elegans to infer anticancer drug mechanisms. Through high-throughput screens of drug-microbe-host interactions, García-González et al. (2017) and Scott et al. (2017) determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug metabolism.

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An Elegan(t) Screen for Drug-Microbe Interactions

Abstract

ASJC Scopus subject areas

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