An electron microscopic study of calcificaton of retinoblastoma

C. Chia Lee Lin, M. O.M. Tso

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We examined three eyes with retinoblastoma that had clinical evidence of calcification. The light and electron microscopic study of the retinoblastoma cells from these eyes disclosed an intramitochondrial calcium deposition after plasmalemma disruption. Morphologically, calcium deposits initially occur as needle-like structures gathered within the mitochondrial membrane. With progressive necrotic liquefaction of tumor cells, microbodies develop a central calcified cone surrounded by an electron-translucent zone with coarse needle-like calcium deposition on the surface.

Original languageEnglish (US)
Pages (from-to)765-774
Number of pages10
JournalAmerican journal of ophthalmology
Issue number6
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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