TY - JOUR
T1 - An atypical case of fatal zygomycosis
T2 - Simultaneous cutaneous and laryngeal infection in a patient with a non-neutropenic solid prostatic tumor
AU - Johnson, Kristine E.
AU - Leahy, Kevin
AU - Owens, Christopher
AU - Blankson, Joel N.
AU - Merz, William G.
AU - Goldstein, Bradley J.
PY - 2008/3
Y1 - 2008/3
N2 - We describe what we believe is the first reported case of simultaneous highly invasive cutaneous and laryngopharyngeal zygomycosis in a non-neutropenic, nondiabetic but immunosuppressed patient with prostate cancer. An invasive fungal process was not suspected until late in the patient's hospital course; when it was, a tracheotomy and direct laryngoscopic biopsies were performed. Unresectable invasive zygomycosis with Rhizopus rhizopodiformis was diagnosed. The patient was managed with liposomal amphotericin B initially and later with palliative medical therapy until he died. This case emphasizes the need for a rapid and specific diagnosis with timely introduction of appropriate antifungal management, particularly now that voriconazole is frequently used as empiric prophy-laxis against aspergillosis in high-risk patients.
AB - We describe what we believe is the first reported case of simultaneous highly invasive cutaneous and laryngopharyngeal zygomycosis in a non-neutropenic, nondiabetic but immunosuppressed patient with prostate cancer. An invasive fungal process was not suspected until late in the patient's hospital course; when it was, a tracheotomy and direct laryngoscopic biopsies were performed. Unresectable invasive zygomycosis with Rhizopus rhizopodiformis was diagnosed. The patient was managed with liposomal amphotericin B initially and later with palliative medical therapy until he died. This case emphasizes the need for a rapid and specific diagnosis with timely introduction of appropriate antifungal management, particularly now that voriconazole is frequently used as empiric prophy-laxis against aspergillosis in high-risk patients.
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U2 - 10.1177/014556130808700311
DO - 10.1177/014556130808700311
M3 - Article
C2 - 18404912
AN - SCOPUS:43549107915
SN - 0145-5613
VL - 87
SP - 152
EP - 155
JO - Eye, ear, nose & throat monthly
JF - Eye, ear, nose & throat monthly
IS - 3
ER -