An association between reduced interhemispheric EEG coherence in the temporal lobe and genetic risk for schizophrenia

Georg Winterer; Michael F. Egan; Thomas Rädler; Thomas Hyde; Richard Coppola; Daniel R. Weinberger

doi:10.1016/S0920-9964(00)00128-6

An association between reduced interhemispheric EEG coherence in the temporal lobe and genetic risk for schizophrenia

Georg Winterer, Michael F. Egan, Thomas Rädler, Thomas Hyde, Richard Coppola, Daniel R. Weinberger

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Previous studies have suggested that schizophrenic patients show resting EEG replicate the results on the second data set. Power spectrum analysis suggested that schizophrenics are cortically hypoactivated, whereas in unaffected siblings, a tendency for hyperactivation was found. In contrast, spectral coherences (0.5-5 Hz) were reduced in both data sets in the temporal lobe areas in schizophrenics and in their unaffected siblings. Changes were most pronounced for the interhemispheric coherence linking both posterior temporal lobe areas. Relative risk calculations (λ_S) ranged between 3.7 and 9.8, depending on phenotype definition. Thus, while power spectrum EEG abnormalities may be state-dependent, reduced coherence as a possible measure of neuronal synchronization is familial and potentially a heritable trait related to genetic risk for schizophrenia.

Original language	English (US)
Pages (from-to)	129-143
Number of pages	15
Journal	Schizophrenia Research
Volume	49
Issue number	1-2
DOIs	https://doi.org/10.1016/S0920-9964(00)00128-6
State	Published - Apr 15 2001
Externally published	Yes

Keywords

Coherence
EEG
Relative risk
Schizophrenia
Sib-pair analysis

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/S0920-9964(00)00128-6

Cite this

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abstract = "Previous studies have suggested that schizophrenic patients show resting EEG replicate the results on the second data set. Power spectrum analysis suggested that schizophrenics are cortically hypoactivated, whereas in unaffected siblings, a tendency for hyperactivation was found. In contrast, spectral coherences (0.5-5 Hz) were reduced in both data sets in the temporal lobe areas in schizophrenics and in their unaffected siblings. Changes were most pronounced for the interhemispheric coherence linking both posterior temporal lobe areas. Relative risk calculations (λS) ranged between 3.7 and 9.8, depending on phenotype definition. Thus, while power spectrum EEG abnormalities may be state-dependent, reduced coherence as a possible measure of neuronal synchronization is familial and potentially a heritable trait related to genetic risk for schizophrenia.",

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AU - Egan, Michael F.

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AU - Hyde, Thomas

AU - Coppola, Richard

AU - Weinberger, Daniel R.

PY - 2001/4/15

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N2 - Previous studies have suggested that schizophrenic patients show resting EEG replicate the results on the second data set. Power spectrum analysis suggested that schizophrenics are cortically hypoactivated, whereas in unaffected siblings, a tendency for hyperactivation was found. In contrast, spectral coherences (0.5-5 Hz) were reduced in both data sets in the temporal lobe areas in schizophrenics and in their unaffected siblings. Changes were most pronounced for the interhemispheric coherence linking both posterior temporal lobe areas. Relative risk calculations (λS) ranged between 3.7 and 9.8, depending on phenotype definition. Thus, while power spectrum EEG abnormalities may be state-dependent, reduced coherence as a possible measure of neuronal synchronization is familial and potentially a heritable trait related to genetic risk for schizophrenia.

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An association between reduced interhemispheric EEG coherence in the temporal lobe and genetic risk for schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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