An animal study of different treatments to prevent postoperative pelvic adhesions

Robert A. Graebe; Terri Lynn Cornelison; Sie‐Bin ‐B Pan; Florence P. Haseltine; Alan H. De Cherney; Gabriel Oelsner

doi:10.1002/micr.1920100110

An animal study of different treatments to prevent postoperative pelvic adhesions

Robert A. Graebe, Terri Lynn Cornelison, Sie‐Bin ‐B Pan, Florence P. Haseltine, Alan H. De Cherney, Gabriel Oelsner

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A study was designed to test various high‐molecular‐weight solutions in the prevention of postoperative intraabdominal adhesions. The bicornuate rat uterus was used as the surgical model, and 80 mature white female rats underwent surgical injury of the right uterine horn. The rats were randomly divided into 5 groups: groups A, B, and C received 5 ml intraperitoneally of chondroitin sulfate, sodium carboxymethylcellulose, and 32% dextran 70, respectively; group D was treated with microsurgical repair; and group E, the control, received no therapy. The animals were killed postoperatively, and the adhesions were scored. Significantly better results in adhesion prevention were demonstrated in the sodium carboxymethylcellulose group vs. the other groups, except in group A where the difference was not significant.

Original language	English (US)
Pages (from-to)	53-55
Number of pages	3
Journal	Microsurgery
Volume	10
Issue number	1
DOIs	https://doi.org/10.1002/micr.1920100110
State	Published - 1989

ASJC Scopus subject areas

Surgery

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abstract = "A study was designed to test various high‐molecular‐weight solutions in the prevention of postoperative intraabdominal adhesions. The bicornuate rat uterus was used as the surgical model, and 80 mature white female rats underwent surgical injury of the right uterine horn. The rats were randomly divided into 5 groups: groups A, B, and C received 5 ml intraperitoneally of chondroitin sulfate, sodium carboxymethylcellulose, and 32% dextran 70, respectively; group D was treated with microsurgical repair; and group E, the control, received no therapy. The animals were killed postoperatively, and the adhesions were scored. Significantly better results in adhesion prevention were demonstrated in the sodium carboxymethylcellulose group vs. the other groups, except in group A where the difference was not significant.",

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AU - Graebe, Robert A.

AU - Cornelison, Terri Lynn

AU - Pan, Sie‐Bin ‐B

AU - Haseltine, Florence P.

AU - De Cherney, Alan H.

AU - Oelsner, Gabriel

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An animal study of different treatments to prevent postoperative pelvic adhesions

Abstract

ASJC Scopus subject areas

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