Amyloidosis in bone

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Amyloidosis is the deposition of protein in the extracellular space of various tissues. It occurs as a manifestation of plasma cell dyscrasia or long-term dialysis. Amyloidosis complicates 5-15 % of cases of multiple myeloma and may present as radiolytic bone lesions that may be solitary, amyloidomas. The most common sites are the skull and spine. The average age of patients is 57 years. Radiologically, amyloidoma of the bone is an expansile lytic lesion; stippled radiodensity may be present. Waxy eosinophilic Congo red-positive deposits are present in the marrow space, synovial membrane, and juxta-articular soft tissues. Plasma cells are monoclonal with kappa and lambda light-chain immunostains. Solitary amyloidoma of the bone almost always progresses to disseminated amyloidosis or multiple myeloma.

Original languageEnglish (US)
Title of host publicationTumors and Tumor-Like Lesions of Bone: For Surgical Pathologists, Orthopedic Surgeons and Radiologists
PublisherSpringer-Verlag London Ltd
Number of pages5
ISBN (Print)9781447165781, 9781447165774
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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