Abstract
Amyloidosis is the deposition of protein in the extracellular space of various tissues. It occurs as a manifestation of plasma cell dyscrasia or long-term dialysis. Amyloidosis complicates 5-15 % of cases of multiple myeloma and may present as radiolytic bone lesions that may be solitary, amyloidomas. The most common sites are the skull and spine. The average age of patients is 57 years. Radiologically, amyloidoma of the bone is an expansile lytic lesion; stippled radiodensity may be present. Waxy eosinophilic Congo red-positive deposits are present in the marrow space, synovial membrane, and juxta-articular soft tissues. Plasma cells are monoclonal with kappa and lambda light-chain immunostains. Solitary amyloidoma of the bone almost always progresses to disseminated amyloidosis or multiple myeloma.
Original language | English (US) |
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Title of host publication | Tumors and Tumor-Like Lesions of Bone: For Surgical Pathologists, Orthopedic Surgeons and Radiologists |
Publisher | Springer-Verlag London Ltd |
Pages | 933-937 |
Number of pages | 5 |
ISBN (Print) | 9781447165781, 9781447165774 |
DOIs | |
State | Published - Jan 1 2015 |
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology