Ampicillin/Sulbactam Versus Ampicillin Alone for Cesarean Section Prophylaxis: A Randomized Double-Blind Trial

A. Rijhsinghani, S. E. Savopoulos, J. K. Walters, G. Huggins, J. R. Hibbs

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


To study the effectiveness of anaerobic coverage in prevention of postpartum endometritis in women undergoing nonelective cesarean sections, we conducted a randomized prospective double-blind study of women undergoing cesarean sections and requiring antibiotic prophylaxis from April 1,1989, through December 31,1990. Ninety-four patients were enrolled in the study. Forty-five patients received ampicillin alone and 46 received ampicillin in conjunction with sulbactam. All patients were evaluated prior to surgery and in the postoperative period. Ninety-one patients completed the study and their records were analyzed. Patients were divided into two groups depending on the presence or absence of ruptured membranes. Seventy-five percent of patients had ruptured membranes. Failure of prophylaxis and subsequent endometritis was documented in 8.8% of patients who received ampicillin and sulbactam and 35.3% of patients who received ampicillin alone. This difference was statistically significant (p < 0.02). In conclusion, single-dose ampicillin and sulbactam provides better prophylaxis than single-dose ampicillin in women undergoing cesarean section with rupture of membranes.

Original languageEnglish (US)
Pages (from-to)322-324
Number of pages3
JournalAmerican journal of perinatology
Issue number5
StatePublished - Sep 1995
Externally publishedYes


  • Sulbactam
  • ampicillin
  • cesarean
  • of membranes
  • prophylaxis
  • rupture
  • section

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


Dive into the research topics of 'Ampicillin/Sulbactam Versus Ampicillin Alone for Cesarean Section Prophylaxis: A Randomized Double-Blind Trial'. Together they form a unique fingerprint.

Cite this