Ampicillin and amoxicillin

Alasdair M. Geddes, Ian M. Gould, Jason A. Roberts, M. Lindsay Grayson, Sara E. Cosgrove

Research output: Chapter in Book/Report/Conference proceedingChapter


Ampicillin and ampicillin-like agents, such as amoxicillin, have many similar properties, but also some important differences. They are all semisynthetic penicillins derived from the penicillin nucleus, but differ in their bioavailability and pharmacokinetic features. The two key agents in this group are ampicillin and amoxicillin, in terms of both their individual properties and the fact that they have both been combined with the beta-lactamase inhibitors, sulbactam (see Chapter 15, Ampicillin-sulbactam) and clavulanic acid (see Chapter 14, Amoxicillin-clavulanic acid), respectively, to broaden their antibacterial spectrum of activity. Ampicillin and amoxicillin will be discussed in detail in this chapter, but information regarding the other, now unused ampicillin-like compounds is summarized in Table 5.1 because they have no special advantages over ampicillin/amoxicillin.

Original languageEnglish (US)
Title of host publicationKucers the Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition
PublisherCRC Press
Number of pages36
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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